Zhang Maolan, Luo Xuanran, Jiang Maocai, Wen Yu, Wang Peng, Chen Peixing, Sun Da
Chongqing Engineering Laboratory of Nano, Micro Biological Medicine Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China.
National & Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Toxics. 2025 Jun 18;13(6):512. doi: 10.3390/toxics13060512.
Polyurethane (PU) is widely employed in the biomedical field. As application scenarios become increasingly complex, it is essential to modify PU to meet diverse requirements. Additionally, the degradation of PU is closely linked to the sustainability of its function, with degradation products having a direct impact on adjacent tissues. In this study, a novel PU containing double bonds in its main chain was developed. We investigated the influence of various ratios of soft segment composition on the degradation performance of PU, maintaining a fixed ratio of soft to hard segments and utilizing specific synthesis methods. The structure and molecular weight of the PU were analyzed using FTIR, NMR, and GPC techniques. The results of physical and chemical performance tests indicated that an increase in polycaprolactone diol (PCL diol) content within the soft segment enhanced the mechanical properties, hydrophobicity, and degradation performance of the PU. A further assessment of the degradation toxicity of PU was carried out using zebrafish as a model organism. The findings indicated that the degradation solution of PU exhibited slight toxicity to zebrafish embryonic development over prolonged degradation periods. However, it also significantly enhanced the hatching of zebrafish embryos. In summary, the novel PU developed in this study demonstrates favorable biocompatibility, and the approach of introducing reaction sites or modifying the composition of its soft segments within the molecular structure offers a promising and effective strategy to address specific application requirements.
聚氨酯（PU）在生物医学领域有着广泛应用。随着应用场景日益复杂，对PU进行改性以满足多样需求至关重要。此外，PU的降解与其功能的可持续性密切相关，降解产物会对相邻组织产生直接影响。在本研究中，开发了一种主链含双键的新型PU。我们在保持软硬段比例固定并采用特定合成方法的情况下，研究了软段组成的不同比例对PU降解性能的影响。使用傅里叶变换红外光谱（FTIR）、核磁共振（NMR）和凝胶渗透色谱（GPC）技术分析了PU的结构和分子量。物理和化学性能测试结果表明，软段中聚己内酯二醇（PCL二醇）含量的增加增强了PU的力学性能、疏水性和降解性能。以斑马鱼作为模式生物对PU的降解毒性进行了进一步评估。结果表明，在较长降解期内，PU的降解溶液对斑马鱼胚胎发育表现出轻微毒性。然而，它也显著提高了斑马鱼胚胎的孵化率。总之，本研究开发的新型PU具有良好的生物相容性，在分子结构中引入反应位点或改变其软段组成的方法为满足特定应用需求提供了一种有前景且有效的策略。
