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生物繁殖/伍斯特大鼠中的脾细胞输血。糖尿病的预防、主要组织相容性复合体限制以及输血细胞的长期存活。

Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

作者信息

Rossini A A, Mordes J P, Greiner D L, Nakano K, Appel M C, Handler E S

出版信息

J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.

DOI:10.1172/JCI112448
PMID:3958191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424507/
Abstract

We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.

摘要

我们报告称，输注RT1u Wistar-Furth（WF）脾细胞可预防RT1u BB/W大鼠的自发性糖尿病，而RT1b水牛大鼠脾细胞则不能。此外，在输血后5个月，在非糖尿病易感性BB/W受体中检测到供体来源的WF T淋巴细胞。供体来源淋巴细胞的存活可能提供了一种细胞机制，通过这种机制，主要组织相容性复合体相容的WF脾细胞输血可预防BB大鼠糖尿病。

相似文献

1
Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.生物繁殖/伍斯特大鼠中的脾细胞输血。糖尿病的预防、主要组织相容性复合体限制以及输血细胞的长期存活。
J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.
2
[An experimental study of spontaneously diabetic Bio Breeding/Worcester (BB/W) rats--with special references to the rat MHC (RT1) in the development of the disease].自发性糖尿病Bio Breeding/Worcester（BB/W）大鼠的实验研究——特别提及大鼠主要组织相容性复合体（RT1）在该疾病发展中的作用
Hokkaido Igaku Zasshi. 1989 May;64(3):349-62.
3
Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.生物繁殖/伍斯特大鼠中的糖尿病。脾细胞条件培养基的诱导和加速作用。
J Clin Invest. 1985 Oct;76(4):1692-4. doi: 10.1172/JCI112156.
4
Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.淋巴细胞输注可预防生物繁殖/伍斯特大鼠患糖尿病。
J Clin Invest. 1984 Jul;74(1):39-46. doi: 10.1172/JCI111416.
5
Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.Bio-Breeding/Worcester大鼠的自发性糖尿病。胰岛细胞自然杀伤细胞裂解的体外证据。
J Clin Invest. 1986 Mar;77(3):916-24. doi: 10.1172/JCI112390.
6
Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.自发性糖尿病BB大鼠严重外周血T淋巴细胞免疫缺陷的鉴定。
J Immunol. 1983 Apr;130(4):1723-31.
7
Spontaneous diabetes mellitus in the rat--a powerful probe of MHC and non-MHC immunogenetic interactions.大鼠自发性糖尿病——MHC与非MHC免疫遗传相互作用的有力研究工具
Transplant Proc. 1982 Sep;14(3):547-9.
8
Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.通过单次输注脾细胞预防BB/Wor大鼠糖尿病。影响保护程度的参数。
Diabetes. 1989 Jan;38(1):24-30. doi: 10.2337/diab.38.1.24.
9
T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.
J Immunol. 1999 May 1;162(9):5134-42.
10
Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.生物繁殖型/伍斯特（BB/W）近交系和杂交大鼠自身免疫性糖尿病的过继转移
J Immunol. 1985 Mar;134(3):1583-7.

引用本文的文献

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Lack of significant de novo HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products.在输注白细胞滤除、ABO血型相同血液制品的心室辅助装置接受者中，缺乏显著的新生HLA同种致敏。
Hum Immunol. 2009 Jun;70(6):413-6. doi: 10.1016/j.humimm.2009.03.001. Epub 2009 Mar 9.
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The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.大鼠和小鼠中ADP核糖基转移酶的RT6（Art2）家族。
Mol Cell Biochem. 1999 Mar;193(1-2):61-8.
3
Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.大鼠中胸腺依赖性和非胸腺依赖性RT6⁺细胞的个体发生及免疫组织化学定位
Am J Pathol. 1996 Jun;148(6):2043-56.
4
Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity.大鼠同种异体血液淋巴微嵌合体与自身免疫性疾病的预防。同种免疫与自身免疫之间的关系。
J Clin Invest. 1996 Jan 1;97(1):217-25. doi: 10.1172/JCI118393.
5
Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.RT6.1+ T淋巴细胞的耗竭会诱导抗性生物繁殖/伍斯特（BB/W）大鼠患糖尿病。
J Exp Med. 1987 Aug 1;166(2):461-75. doi: 10.1084/jem.166.2.461.
6
Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat.富含W3/25 +辅助/诱导性T淋巴细胞的输血可预防BB/W大鼠的自发性糖尿病。
Diabetologia. 1987 Jan;30(1):22-6. doi: 10.1007/BF01788902.

本文引用的文献

1
RECIRCULATION OF LYMPHOCYTES.淋巴细胞的再循环
Ann N Y Acad Sci. 1964 Feb 28;113:887-97. doi: 10.1111/j.1749-6632.1964.tb40710.x.
2
The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man.“BB”系Wistar大鼠的糖尿病综合征：与人类1型（胰岛素依赖型）糖尿病的可能关联。
Diabetologia. 1982 Apr;22(4):225-32. doi: 10.1007/BF00281296.
3
Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.大鼠自发性糖尿病综合征。I. 与主要组织相容性复合体的关联
J Exp Med. 1981 Oct 1;154(4):1237-42. doi: 10.1084/jem.154.4.1237.
4
Early stages of lymphocyte development.淋巴细胞发育的早期阶段。
Curr Top Dev Biol. 1980;14(Pt 2):33-57. doi: 10.1016/s0070-2153(08)60188-x.
5
Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome.“BB”大鼠的淋巴细胞减少和异常淋巴细胞亚群：与糖尿病综合征的关系。
Endocrinology. 1982 May;110(5):1825-7. doi: 10.1210/endo-110-5-1825.
6
The BB diabetic rat. Profound T-cell lymphocytopenia.BB糖尿病大鼠。严重的T细胞淋巴细胞减少症。
Diabetes. 1981 Oct;30(10):887-9. doi: 10.2337/diab.30.10.887.
7
Genetic analysis of the BB/W diabetic rat.BB/W糖尿病大鼠的基因分析。
Can J Genet Cytol. 1983 Feb;25(1):7-15. doi: 10.1139/g83-002.
8
Passive transfer of diabetes in the BB/W rat.BB/W大鼠糖尿病的被动转移
Science. 1983 May 13;220(4598):727-8. doi: 10.1126/science.6836309.
9
Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.输注全血可预防BB/W大鼠患自发性糖尿病。
Science. 1983 Feb 25;219(4587):975-7. doi: 10.1126/science.6823559.
10
Gastric parietal cell and other autoantibodies in the BB rat.BB大鼠中的胃壁细胞及其他自身抗体。
Diabetes. 1982 Apr;31(4 Pt 1):313-8. doi: 10.2337/diab.31.4.313.