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Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

作者信息

Rossini A A, Mordes J P, Greiner D L, Nakano K, Appel M C, Handler E S

出版信息

J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.

Abstract

We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.

摘要

相似文献

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Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.
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本文引用的文献

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