Rossini A A, Mordes J P, Greiner D L, Nakano K, Appel M C, Handler E S
J Clin Invest. 1986 Apr;77(4):1399-401. doi: 10.1172/JCI112448.
We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.