Pignataro Patrizia, Dicarlo Manuela, Zecca Chiara, Urso Daniele, Dell'Abate Maria Teresa, Vilella Davide, Borlizzi Francesco, Zerlotin Roberta, Oranger Angela, Colaianni Graziana, Colucci Silvia, Grano Maria, Logroscino Giancarlo
Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "A. Moro", Bari, Italy.
Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "A. Moro", Bari, Italy.
Ann Clin Transl Neurol. 2025 Jun 25. doi: 10.1002/acn3.70117.
The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients. Thus, in the present study, we investigated the association of irisin with multidomain cognition in patients showing dementia-related symptomatology.
Cerebrospinal fluid (CSF) and serum irisin levels were evaluated using enzyme-linked immunoassays in a cohort of subjects with a confirmed biomarker evidence of AD, including AD (n = 82), mild cognitive impairment (MCI, n = 44), and subjective memory complaint (SMC, n = 20) patients. The results of this analysis were correlated with global cognitive efficiency assessed by Mini-Mental State Examination, and multidomain cognition evaluated by a battery of psychometric tests.
Decreased CSF and serum irisin levels were observed in AD and MCI patients compared to SMC. A significant correlation has been found between irisin in the CSF and global cognitive efficiency, as well as with specific cognitive domains such as memory, executive functions, attention, visuospatial abilities, and language. For serum irisin, the correlation analysis evidenced similar results to those observed for the CSF.
Our results highlight the key involvement of irisin in multidomain cognition, indicating its potential role as a cognitive biomarker of AD progression.
肌动蛋白鸢尾素是近期发现的一种大脑运动正向调节因子，具有对抗阿尔茨海默病（AD）的神经保护功能。鸢尾素与认知之间的关联从未在生物学定义明确的患者队列中进行过研究。因此，在本研究中，我们调查了鸢尾素与出现痴呆相关症状的患者多领域认知之间的关联。
采用酶联免疫分析法对一组确诊为AD生物标志物阳性的受试者进行脑脊液（CSF）和血清鸢尾素水平评估，这些受试者包括AD患者（n = 82）、轻度认知障碍（MCI，n = 44）患者和主观记忆障碍（SMC，n = 20）患者。该分析结果与简易精神状态检查表评估的整体认知效率以及一系列心理测量测试评估的多领域认知相关。
与SMC患者相比，AD和MCI患者的脑脊液和血清鸢尾素水平降低。脑脊液中的鸢尾素与整体认知效率以及记忆、执行功能、注意力、视觉空间能力和语言等特定认知领域之间存在显著相关性。对于血清鸢尾素，相关性分析结果与脑脊液观察结果相似。
我们的结果突出了鸢尾素在多领域认知中的关键作用，表明其作为AD进展认知生物标志物的潜在作用。
