Hahn E G
J Hepatol. 1985;1(1):67-73. doi: 10.1016/s0168-8278(85)80069-6.
Liver fibrosis is one of the most important factors of disturbed liver function, but could not be measured by simple blood tests until recently. Among several parameters used for this purpose, the aminoterminal procollagen type III peptide (PIIIP) appears to be the most widely accepted. Studies conducted in several clinical groups have shown that PIIIP effectively distinguishes between non-fibrotic and fibrotic liver disease. A reliable commercial kit is available and a wide application possible to evaluate the clinical meaning of serum PIIIP for the long-term outcome of chronic liver disease. With this novel blood test we can now assess liver fibrosis as we can measure the hepato-biliary function.
肝纤维化是肝功能紊乱的最重要因素之一，但直到最近还无法通过简单的血液检测来测定。在用于此目的的几个参数中，Ⅲ型前胶原氨基端肽（PIIIP）似乎是最被广泛接受的。在多个临床组中进行的研究表明，PIIIP能有效区分非纤维化和纤维化肝病。有可靠的商业试剂盒可供使用，并且有可能广泛应用于评估血清PIIIP对慢性肝病长期预后的临床意义。有了这种新型血液检测方法，我们现在就能够像测量肝胆功能一样评估肝纤维化。
