类风湿关节炎患者血清Ⅲ型前胶原氨基端肽和血清透明质酸：与左旋咪唑、青霉胺或硫唑嘌呤治疗8个月和24个月期间炎症的临床及血清学参数的关系
Serum amino terminal type III procollagen peptide and serum hyaluronan in rheumatoid arthritis: relation to clinical and serological parameters of inflammation during 8 and 24 months' treatment with levamisole, penicillamine, or azathioprine.
作者信息
Hørslev-Petersen K, Bentsen K D, Engström-Laurent A, Junker P, Halberg P, Lorenzen I
机构信息
Department of Medicine, University of Copenhagen, Hvidovre Hospital, Denmark.
出版信息
Ann Rheum Dis. 1988 Feb;47(2):116-26. doi: 10.1136/ard.47.2.116.
Abstract
Increased serum levels of the amino terminal type III procollagen peptide and serum hyaluronan were demonstrated in patients with rheumatoid arthritis. In patients with active disease a significant correlation was shown between serum levels of the propeptide and hyaluronan and the clinical signs of synovitis reflecting the extent of synovial inflammation. During recovery the serum propeptide and serum hyaluronan showed a delayed decline as compared with the clinical signs of synovitis and the acute phase protein response. This probably reflects the presence of persistent subclinical chronic inflammation. Normal serum propeptide levels in rheumatoid arthritis were associated with a good prognosis without progression of erosive joint lesions. Azathioprine reduced the number of patients with progression of erosive joint lesions and caused a more marked suppression of the serum propeptide than levamisole and penicillamine.
摘要
类风湿关节炎患者血清Ⅲ型前胶原氨基端肽和血清透明质酸水平升高。在活动期疾病患者中，前肽和透明质酸的血清水平与反映滑膜炎程度的滑膜炎临床体征之间存在显著相关性。在恢复过程中，与滑膜炎临床体征和急性期蛋白反应相比，血清前肽和血清透明质酸水平下降延迟。这可能反映了持续性亚临床慢性炎症的存在。类风湿关节炎患者血清前肽水平正常与无侵蚀性关节病变进展的良好预后相关。硫唑嘌呤减少了侵蚀性关节病变进展的患者数量，并且比左旋咪唑和青霉胺更显著地抑制血清前肽。
相似文献
1
Serum amino terminal type III procollagen peptide and serum hyaluronan in rheumatoid arthritis: relation to clinical and serological parameters of inflammation during 8 and 24 months' treatment with levamisole, penicillamine, or azathioprine.类风湿关节炎患者血清Ⅲ型前胶原氨基端肽和血清透明质酸：与左旋咪唑、青霉胺或硫唑嘌呤治疗8个月和24个月期间炎症的临床及血清学参数的关系
Ann Rheum Dis. 1988 Feb;47(2):116-26. doi: 10.1136/ard.47.2.116.
2
Serum amino-terminal type III procollagen peptide in rheumatoid arthritis. Relationship to disease activity, treatment, and development of joint erosions.类风湿关节炎中的血清Ⅲ型前胶原氨基端肽。与疾病活动度、治疗及关节侵蚀发展的关系。
Arthritis Rheum. 1986 May;29(5):592-9. doi: 10.1002/art.1780290503.
4
[Serum hyaluronic acid and aminoterminal procollagen III peptide in inflammatory and degenerative joint diseases].炎症性和退行性关节疾病中的血清透明质酸和Ⅲ型前胶原氨基端肽
Z Rheumatol. 1988 Mar-Apr;47(2):98-106.
5
The aminoterminal-type-III procollagen peptide and proteoglycans in serum and synovial fluid of patients with rheumatoid arthritis or reactive arthritis.类风湿性关节炎或反应性关节炎患者血清和滑液中的氨基末端III型前胶原肽和蛋白聚糖。
Rheumatol Int. 1988;8(1):1-9. doi: 10.1007/BF00541343.
6
Serum aminoterminal type III procollagen peptide and the 7S domain of type IV collagen in patients with alcohol abuse. Relation to ultrastructural fibrosis in the acinar zone 3 and to serum hyaluronan.酒精滥用患者血清Ⅲ型前胶原氨基端肽及Ⅳ型胶原7S结构域与腺泡3区超微结构纤维化及血清透明质酸的关系
Liver. 1987 Dec;7(6):339-46. doi: 10.1111/j.1600-0676.1987.tb00365.x.
7
8
9
Acute phase proteins and clinical synovitis activity in patients with rheumatoid arthritis.
Clin Rheumatol. 1987 Jun;6(2):226-32. doi: 10.1007/BF02201028.
引用本文的文献
1
Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms.重新审视循环细胞外基质片段作为骨髓纤维化及相关肿瘤的疾病标志物
Cancers (Basel). 2023 Aug 29;15(17):4323. doi: 10.3390/cancers15174323.
2
Cellular protein markers, therapeutics, and drug delivery strategies in the treatment of diabetes-associated liver fibrosis.细胞蛋白标志物、治疗方法和药物递送策略在治疗糖尿病相关肝纤维化中的应用。
Adv Drug Deliv Rev. 2021 Jul;174:127-139. doi: 10.1016/j.addr.2021.04.008. Epub 2021 Apr 20.
3
Serum hyaluronic acid levels in patients with ankylosing spondylitis.强直性脊柱炎患者的血清透明质酸水平
Clin Rheumatol. 2008 May;27(5):621-6. doi: 10.1007/s10067-007-0757-0. Epub 2007 Oct 23.
4
Serum hyaluronan levels in patients with knee osteoarthritis.膝骨关节炎患者的血清透明质酸水平
Clin Rheumatol. 2007 Aug;26(8):1293-8. doi: 10.1007/s10067-006-0499-4. Epub 2007 Jan 5.
5
Synovial fluid and serum concentrations of aminoterminal propeptide of type III procollagen in healthy volunteers and patients with joint disease.健康志愿者和关节疾病患者的滑液及血清中III型前胶原氨基端前肽的浓度
Ann Rheum Dis. 1996 Jan;55(1):47-51. doi: 10.1136/ard.55.1.47.
6
Seromarkers of collagen I and III metabolism in active Crohn's disease. Relation to disease activity and response to therapy.活动期克罗恩病中I型和III型胶原代谢的血清标志物。与疾病活动及治疗反应的关系。
Gut. 1995 Dec;37(6):805-10. doi: 10.1136/gut.37.6.805.
7
Effects of cyclosporin on serum hyaluronan levels in collagen arthritis.环孢素对胶原性关节炎血清透明质酸水平的影响。
Inflamm Res. 1995 Feb;44(2):79-82. doi: 10.1007/BF01793217.
8
Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing.透明质酸。对其药理学以及在眼科手术辅助中的应用，及其在关节疾病和伤口愈合方面治疗潜力的综述。
Drugs. 1994 Mar;47(3):536-66. doi: 10.2165/00003495-199447030-00009.
9
Application of markers of collagen metabolism in serum and synovial fluid for assessment of disease process in patients with rheumatoid arthritis.血清和滑液中胶原代谢标志物在类风湿关节炎患者疾病进程评估中的应用
Ann Rheum Dis. 1995 Nov;54(11):886-90. doi: 10.1136/ard.54.11.886.
10
Serum aminoterminal type III procollagen peptide in inflammatory and degenerative rheumatic disorders.炎症性和退行性风湿性疾病中的血清氨基末端III型前胶原肽
Clin Rheumatol. 1988 Mar;7(1):61-8. doi: 10.1007/BF02284058.
本文引用的文献
1
A new radioimmunoassay for IgM and IgG rheumatoid factors, based on a double antibody method.一种基于双抗体法的新型IgM和IgG类风湿因子放射免疫测定法。
J Immunol Methods. 1981;47(1):87-97. doi: 10.1016/0022-1759(81)90259-3.
2
The collagens of the joint.关节的胶原蛋白
Arthritis Rheum. 1980 Aug;23(8):937-41. doi: 10.1002/art.1780230810.
3
Enzymes of collagen synthesis and type III procollagen aminopropeptide in the evaluation of D-penicillamine and medroxyprogesterone treatments of primary biliary cirrhosis.在评估青霉胺和甲羟孕酮治疗原发性胆汁性肝硬化时的胶原合成酶及Ⅲ型前胶原氨基端肽
Gut. 1983 Feb;24(2):136-42. doi: 10.1136/gut.24.2.136.
4
5
Serum and urine analysis of the aminoterminal procollagen peptide type III by radioimmunoassay with antibody Fab fragments.采用抗体Fab片段放射免疫分析法对血清和尿液中的III型前胶原氨基端肽进行分析。
Coll Relat Res. 1983 Sep;3(5):371-9. doi: 10.1016/s0174-173x(83)80018-1.
6
Clinical synovitis and radiological lesions in rheumatoid arthritis. A prospective study of 25 patients during treatment with remission-inducing drugs.类风湿关节炎的临床滑膜炎和放射学病变。对25例使用缓解诱导药物治疗的患者进行的前瞻性研究。
Scand J Rheumatol. 1983;12(3):237-40. doi: 10.3109/03009748309098540.
7
Circulating immune complexes in rheumatoid arthritis with extra-articular manifestations.伴有关节外表现的类风湿关节炎中的循环免疫复合物
Scand J Rheumatol. 1983;12(3):215-8. doi: 10.3109/03009748309098536.
8
Steroid treatment lowers hepatic fibroplasia, as explored by serum aminoterminal procollagen III peptide, in chronic liver disease.
Liver. 1984 Dec;4(6):348-52. doi: 10.1111/j.1600-0676.1984.tb00950.x.
9
Long-term follow-up of serum N-terminal propeptide of collagen type III levels in patients with chronic liver disease.慢性肝病患者血清III型前胶原氨基端前肽水平的长期随访
Hepatology. 1984 Sep-Oct;4(5):835-8. doi: 10.1002/hep.1840040506.
10
Scleroderma skin--conflicting mucopolysaccharide data reflect stages in connective tissue maturation.硬皮病皮肤——相互矛盾的黏多糖数据反映了结缔组织成熟的阶段。
J Rheumatol. 1980 Mar-Apr;7(2):128-9.
Zotero 插件