Rossi Franca, Santonicola Serena, Giaccone Valerio, Truant Alessandro, Colavita Giampaolo
Dipartimento di Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.
Dipartimento di Medicina animale, Produzioni e Salute, Università di Padova, Agripolis, Viale dell'Università 16, 35020 Legnaro, Italy.
Biomolecules. 2025 Jun 17;15(6):886. doi: 10.3390/biom15060886.
This review summarizes the current knowledge on the probiotic characteristics of dairy propionibacteria, represented by and some species commonly consumed through raw milk cheese. For example, in Swiss-type cheeses, is added as a starter culture. Some strains of have been included in mixed probiotic commercial preparations or used to produce tablets from fermented culture media containing bioactive substances such as short-chain fatty acids (SCFAs), bifidogenic molecules, and vitamins. and strains have mainly been evaluated as health and productivity promoters in farm animals. For , the molecular mechanisms behind its probiotic action have been well elucidated, and recently, novel potential applications have been demonstrated in animal models. strains have been shown to mitigate inflammatory bowel diseases (IBDs) and mucositis and prevent necrotizing enterocolitis (NEC) in newborns. Their immunomodulation capacity has alleviated symptoms of food allergies, obesity, diabetes, colorectal cancer (CRC), and infections. Moreover, inhibited osteoclastogenesis in a rheumatoid arthritis model. Most observed effects are mediated by proteins on the cell surface or contained in extracellular vesicles (EVs) such as the surface layer (S-layer) protein SlpB, DlaT, and GroEL. No safety issues have been reported for these bacteria. However, investigations into transferable antibiotic resistance traits are still needed, and clinical trials are required to evaluate their effectiveness as probiotics for humans.
本综述总结了以某些通常通过生牛奶奶酪食用的丙酸杆菌属物种为代表的乳制品丙酸杆菌益生菌特性的现有知识。例如，在瑞士型奶酪中，丙酸杆菌属作为发酵剂添加。一些丙酸杆菌菌株已被纳入混合益生菌商业制剂中，或用于从含有生物活性物质（如短链脂肪酸（SCFAs）、双歧因子分子和维生素）的发酵培养基中生产片剂。丙酸杆菌属和丙酸蛛网菌菌株主要被评估为农场动物健康和生产力的促进剂。对于丙酸杆菌属，其益生菌作用背后的分子机制已得到充分阐明，最近，在动物模型中已证明了其新的潜在应用。丙酸杆菌属菌株已被证明可减轻炎症性肠病（IBDs）和粘膜炎，并预防新生儿坏死性小肠结肠炎（NEC）。它们的免疫调节能力减轻了食物过敏、肥胖、糖尿病、结直肠癌（CRC）和感染的症状。此外，丙酸杆菌属在类风湿性关节炎模型中抑制破骨细胞生成。观察到的大多数效应是由细胞表面的蛋白质或细胞外囊泡（EVs）中所含的蛋白质介导的，如表层（S层）蛋白SlpB、DlaT和GroEL。尚未有关于这些细菌的安全问题报道。然而，仍需要对可转移的抗生素耐药性状进行调查，并且需要进行临床试验来评估它们作为人类益生菌的有效性。
