Lubbers Brian V, Warren Andi, White Bradley J, Torres Siddartha, Rodriguez Pedro
Department of Clinical Sciences and Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA.
Veterinary Medical Library, Kansas State University, Manhattan, KS 66506, USA.
Animals (Basel). 2025 Jun 18;15(12):1789. doi: 10.3390/ani15121789.
Bovine respiratory disease (BRD) is the most significant disease challenge in the feeder cattle industry in North America. Antimicrobials are commonly administered in BRD cases due to the role of bacterial pathogens. However, reports of antimicrobial resistance (AMR) in these pathogens raise concerns regarding their long-term effectiveness to treat BRD cases. A systematic literature review was conducted to summarize AMR in North American BRD pathogens and determine if changes in AMR prevalence over time could be identified for antimicrobials routinely used for treatment and control of BRD. Generalized linear models were used to test associations between the proportion of resistant isolates for each of the three bacterial agents and antimicrobial agent, isolation year, and timing of sample collection. The antimicrobial agent and timing of sample collection were significantly associated with the proportion of antimicrobial resistant isolates, with increased probability of resistance to tulathromycin seen in (24.08%) and (8.19%) and increased resistance to tildipirosin in (21.48%), while samples collected at arrival demonstrated a lower proportions of resistant bacteria. Trends over time could not be evaluated due to the limited number of published studies. These findings highlight the differences in AMR seen between antimicrobials, BRD pathogens, and sample types and emphasize the need for continued AMR surveillance.
牛呼吸道疾病（BRD）是北美育肥牛行业面临的最重大疾病挑战。由于细菌性病原体的作用，抗菌药物常用于治疗BRD病例。然而，这些病原体中抗菌药物耐药性（AMR）的报告引发了人们对其治疗BRD病例长期有效性的担忧。本研究进行了一项系统文献综述，以总结北美BRD病原体中的AMR情况，并确定是否能够识别出常用于治疗和控制BRD的抗菌药物的AMR流行率随时间的变化。使用广义线性模型来检验三种细菌病原体中每种病原体的耐药菌株比例与抗菌药物、分离年份和样本采集时间之间的关联。抗菌药物和样本采集时间与抗菌药物耐药菌株的比例显著相关，在[具体年份1]（24.08%）和[具体年份2]（8.19%）观察到对图拉霉素耐药的概率增加，在[具体年份3]（21.48%）观察到对替地珠单抗耐药性增加，而在到达时采集的样本显示耐药细菌比例较低。由于已发表研究数量有限，无法评估随时间的趋势。这些发现突出了抗菌药物、BRD病原体和样本类型之间AMR的差异，并强调了持续进行AMR监测的必要性。
