Jacobsen E, Billings J K, Frantz R A, Kinney C K, Stewart M E, Downing D T
J Invest Dermatol. 1985 Nov;85(5):483-5. doi: 10.1111/1523-1747.ep12277224.
Sustainable rates of sebaceous wax ester secretion were measured on the foreheads of 109 men and 167 women, aged 15-97. Each measurement was made after first depleting the cutaneous sebum reservoir by overnight absorption of lipid into a layer of bentonite clay. Lipid was then absorbed for 3 h into fresh clay in which two 2-cm cloth disks were embedded. The absorbed lipid was extracted from the disks with ether and analyzed for wax esters by thin-layer chromatography. For both men and women there was a wide range of wax ester secretion rates at all ages. Rates were highest in the 15- to 35-year-olds and appeared to decline continuously throughout the adult age range. Values of log(wax esters) were better correlated with age than the untransformed values of wax ester secretion. The equations of best fit of log(wax esters) vs age suggested that sebum secretion declines about 23% per decade in men and 32% per decade in women.
对年龄在15至97岁之间的109名男性和167名女性的前额皮脂腺蜡酯分泌率进行了持续测量。每次测量前，先通过将脂质过夜吸收到一层膨润土中来耗尽皮肤皮脂储存库。然后，脂质在含有两个2厘米布盘的新鲜粘土中吸收3小时。从布盘中用乙醚提取吸收的脂质，并通过薄层色谱法分析蜡酯。男性和女性在所有年龄段的蜡酯分泌率都有很大差异。15至35岁人群的分泌率最高，且在整个成年年龄段似乎持续下降。蜡酯分泌的对数值与年龄的相关性比蜡酯分泌的未转换值更好。蜡酯分泌对数值与年龄的最佳拟合方程表明，男性皮脂分泌每十年下降约23%，女性每十年下降约32%。
