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作者信息

Khan Ayyad Zartasht, Fineide Fredrik, Wohlmann Jens, Gundersen Kjell Gunnar, Gundersen Morten, Kolko Miriam, Utheim Tor Paaske

机构信息

Department of Ophthalmology, Østfold Hospital Trust, 1524 Moss, Norway.

Department of Ophthalmology, Sørlandet Hospital Trust, 4838 Arendal, Norway.

出版信息

Diagnostics (Basel). 2025 Jun 15;15(12):1520. doi: 10.3390/diagnostics15121520.

DOI:10.3390/diagnostics15121520
PMID:40564840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12191991/
Abstract

Herein, we present scanning electron microscopy imagery of on the eyelashes of a patient with a two-year history of dry, burning, and watery eyes. mites are part of the normal human skin flora, inhabiting hair follicles and sebaceous glands. However, in some individuals, they may contribute to ocular surface diseases, including blepharitis and dry eye disease. Symptoms often include itching, photophobia, and a foreign body sensation. The pathogenic role of is not fully understood but may involve microabrasions, gland obstruction, hypersensitivity reactions, and bacterial dysbiosis. The presence of collarettes at the base of eyelashes is a diagnostic hallmark. Although optimal treatment remains debated, options include topical tea tree oil, ivermectin, and a recently FDA-approved drug lotilaner. Our patient responded favorably to a two-month regimen of tea tree oil-based eyelid wipes. This case underscores the clinical relevance of infestation in chronic ocular discomfort and highlights the importance of diagnostics.

摘要

在此,我们展示了一名有两年眼睛干涩、灼痛和流泪病史患者睫毛上的扫描电子显微镜图像。螨虫是人类正常皮肤菌群的一部分,栖息于毛囊和皮脂腺。然而,在一些个体中,它们可能导致眼表疾病,包括睑缘炎和干眼病。症状通常包括瘙痒、畏光和异物感。螨虫的致病作用尚未完全了解,但可能涉及微擦伤、腺体阻塞、过敏反应和细菌失调。睫毛根部出现衣领样皮屑是一个诊断标志。尽管最佳治疗方案仍存在争议,但选择包括局部茶树油、伊维菌素和最近美国食品药品监督管理局批准的药物洛替拉奈。我们的患者对为期两个月的茶树油基眼睑擦拭治疗方案反应良好。该病例强调了螨虫感染在慢性眼部不适中的临床相关性,并突出了诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/622c/12191991/3d5cf9cf9d59/diagnostics-15-01520-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/622c/12191991/3d5cf9cf9d59/diagnostics-15-01520-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/622c/12191991/3d5cf9cf9d59/diagnostics-15-01520-g001.jpg

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本文引用的文献

1
Expanding the field of view - a simple approach for interactive visualisation of electron microscopy data.扩展视野 - 一种用于电子显微镜数据交互式可视化的简单方法。
J Cell Sci. 2024 Oct 15;137(20). doi: 10.1242/jcs.262198. Epub 2024 Oct 23.
2
Lotilaner Ophthalmic Solution 0.25%: First Approval.Lotilaner 眼科溶液 0.25%:首次批准。
Drugs. 2023 Nov;83(16):1537-1541. doi: 10.1007/s40265-023-01947-9.
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The Use of Digital PCR for the Diagnosis of Blepharitis.应用数字 PCR 诊断睑缘炎
Curr Eye Res. 2024 Jan;49(1):33-38. doi: 10.1080/02713683.2023.2265083. Epub 2024 Jan 3.
4
Demodex Blepharitis: A Comprehensive Review of the Disease, Current Management, and Emerging Therapies.睑缘蠕形螨病:疾病的全面综述、当前管理及新兴疗法。
Eye Contact Lens. 2023 Aug 1;49(8):311-318. doi: 10.1097/ICL.0000000000001003. Epub 2023 Jun 2.
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The Prevalence of Blepharitis in US Eye Care Clinic Patients as Determined by Collarettes: A Pathognomonic Sign.通过睑缘环(一种具有诊断意义的体征)确定美国眼科护理门诊患者睑缘炎的患病率。
Clin Ophthalmol. 2022 Apr 15;16:1153-1164. doi: 10.2147/OPTH.S354692. eCollection 2022.
6
Interventions for Demodex blepharitis and their effectiveness: A systematic review and meta-analysis.干预措施治疗蠕形螨性睑缘炎及其疗效的系统评价和 Meta 分析。
Cont Lens Anterior Eye. 2021 Dec;44(6):101453. doi: 10.1016/j.clae.2021.101453. Epub 2021 May 7.
7
Tea tree oil for Demodex blepharitis.茶树油治疗睑缘蠕形螨睑缘炎。
Cochrane Database Syst Rev. 2020 Jun 20;6(6):CD013333. doi: 10.1002/14651858.CD013333.pub2.
8
Efficacy of treatments for Demodex blepharitis: A systematic review and meta-analysis.治疗蠕形螨性睑缘炎的疗效:系统评价和荟萃分析。
Ocul Surf. 2019 Oct;17(4):655-669. doi: 10.1016/j.jtos.2019.06.004. Epub 2019 Jun 20.
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Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis.强脉冲光治疗眼蠕形螨病的疗效。
Curr Eye Res. 2019 Mar;44(3):250-256. doi: 10.1080/02713683.2018.1536217. Epub 2018 Oct 25.
10
Demodicosis caused by Demodex canis and Demodex cornei in dogs.犬蠕形螨和犬毛囊蠕形螨引起的犬蠕形螨病。
J Parasit Dis. 2015 Dec;39(4):673-6. doi: 10.1007/s12639-013-0405-3. Epub 2013 Nov 26.