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羧甲基纤维素的纯化降低了聚肌胞苷酸-聚肌苷酸在小鼠中的毒性。

Purification of carboxymethylcellulose decreases toxicity of poly ICLC in mice.

作者信息

Bello J, O'Malley J, Granados E

出版信息

J Interferon Res. 1985 Summer;5(3):429-30. doi: 10.1089/jir.1985.5.429.

DOI:10.1089/jir.1985.5.429
PMID:4056490
Abstract

The interferon inducer poly ICLC has toxic side effects; the carboxymethylcellulose (CMC) component is a possible source of this toxicity. We have purified CMC by ethanol extraction, and found that poly ICLC made with purified CMC is not significantly different in its effectiveness as an interferon inducer in mice than poly ICLC made with unpurified CMC, but is less toxic.

摘要

干扰素诱导剂聚肌胞苷酸-聚肌苷酸[poly ICLC]有副作用；羧甲基纤维素（CMC）成分可能是这种毒性的来源。我们通过乙醇提取法纯化了CMC，发现用纯化后的CMC制成的聚肌胞苷酸-聚肌苷酸[poly ICLC]作为小鼠干扰素诱导剂的效果与用未纯化的CMC制成的聚肌胞苷酸-聚肌苷酸[poly ICLC]相比无显著差异，但毒性较小。

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Purification of carboxymethylcellulose decreases toxicity of poly ICLC in mice.羧甲基纤维素的纯化降低了聚肌胞苷酸-聚肌苷酸在小鼠中的毒性。
J Interferon Res. 1985 Summer;5(3):429-30. doi: 10.1089/jir.1985.5.429.
2
Preparation and assay of poly ICL-CM dextran, an interferon inducer of reduced toxicity.毒性降低的干扰素诱导剂聚ICL-CM葡聚糖的制备与测定
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Poly ICL-CM dextran: an interferon inducer of reduced toxicity.聚ICL-羧甲基葡聚糖：一种毒性降低的干扰素诱导剂。
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