Kosztulska Bernadetta, Bartuzi Zbigniew, Ukleja-Sokołowska Natalia
Department and Clinic of Allergology, Clinical Immunology and Internal Diseases, Jan Biziel University Hospital No. 2 in Bydgoszcz, Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Department and Clinic of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland.
Int J Mol Sci. 2025 Jun 18;26(12):5840. doi: 10.3390/ijms26125840.
Celery allergy is a common food allergy, particularly among the European population. Currently, several diagnostic methods are available, including multiplex assays, which are useful for identifying celery-allergic patients. However, all of these methods have certain limitations. Api g 7 is a newly identified celeriac allergen belonging to the defensin protein family. Its clinical relevance lies in the high risk of severe systemic reactions among patients sensitized to this molecule. Patients sensitized to Api g 7 are often co-sensitized to Art v 1, the major mugwort () allergen, due to structural similarity between these two molecules. This molecular homology plays a key role in the pathogenesis of celery-mugwort syndrome. Although Api g 7may be a major celery allergen, none of the currently available commercial diagnostic tests are capable of detecting sIgE against it. This highlights the need for the development of new, commercially available diagnostic tools in allergology.
芹菜过敏是一种常见的食物过敏，在欧洲人群中尤为常见。目前，有几种诊断方法可供使用，包括多重检测，这对识别芹菜过敏患者很有用。然而，所有这些方法都有一定的局限性。Api g 7是一种新发现的芹菜过敏原，属于防御素蛋白家族。其临床相关性在于对该分子致敏的患者发生严重全身反应的风险较高。由于这两种分子之间的结构相似性，对Api g 7致敏的患者通常也会对主要的艾蒿过敏原Art v 1致敏。这种分子同源性在芹菜-艾蒿综合征的发病机制中起关键作用。尽管Api g 7可能是主要的芹菜过敏原，但目前可用的商业诊断测试都无法检测针对它的特异性IgE。这凸显了在过敏学领域开发新的商业可用诊断工具的必要性。
