Department and Clinic of Allergology, Clinical Immunology and Internal Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
Department of Gastroenterology and Nutrition Disorders, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320231223004. doi: 10.1177/03946320231223004.
The symptoms of celery allergy are mainly presented as oral allergy symptom, but there are several case reports of patients who experienced anaphylaxis. Defensin (Api g 7), as a novel allergen in celery root, was described in 2022 r. The female patient had a history of several episodes of dyspnea and cough, associated with ingestion of spice mixes containing dried celery. Up to the point of hospitalization, there were no objective tests, either sIgE or skin prick tests, that would confirm celery sensitization. During hospitalization, patient had a positive double-blind placebo-controlled food challenge with cooked celery. The patient was sensitized to mugwort defensin Art v 1. An inhibition assay with celery allergen extract was performed to prove cross-sensitization between Art v 1 and celery allergen responsible for symptoms in the patient. In conclusion, Api g 7 is an important celery allergen that can be responsible for severe reactions. Its cross-reactivity with Art v 1 is characteristic. Negative diagnostic tests with celery do not exclude Api g 7 sensitization.
芹菜过敏的症状主要表现为口腔过敏症状，但也有几例报告称患者发生了过敏反应。防御素（Api g 7）是芹菜根中的一种新型过敏原，于 2022 年被描述。该女性患者有多次呼吸困难和咳嗽的病史，与食用含有干芹菜的香料混合物有关。在住院之前，没有任何客观的测试（无论是 sIgE 还是皮肤点刺试验）可以确认对芹菜的敏感性。住院期间，患者对煮熟的芹菜进行了双盲安慰剂对照食物挑战，结果呈阳性。该患者对艾蒿防御素 Art v 1 过敏。进行了芹菜过敏原提取物的抑制试验，以证明症状患者中 Art v 1 和负责症状的芹菜过敏原之间存在交叉致敏。总之，Api g 7 是一种重要的芹菜过敏原，可引起严重反应。它与 Art v 1 的交叉反应具有特征性。对芹菜进行的阴性诊断性测试不能排除 Api g 7 的致敏性。
