Lax Tair, Stemmer Edia, Fallach Noga, Shrem Guy, Schreiber-Divon Michal, Ayalon Snait, Giat Eitan, Mor Inbal, Salmon-Divon Mali
Department of Molecular Biology, Ariel University, Ariel 4070000, Israel.
Fertility Clinic, North District, Clalit Health Services, Migdal HaEmek 2303001, Israel.
J Clin Med. 2025 Jun 10;14(12):4090. doi: 10.3390/jcm14124090.
: Psoriasis is a chronic inflammatory skin disease characterized by a bimodal onset distribution, with cases categorized as early-onset or late-onset. While the prevalence of psoriasis is nearly equal between genders, men typically experience more severe forms of the disease, leading to differences in treatment approaches and clinical outcomes. The aim of this study was to investigate gender-based differences in treatment patterns among psoriasis patients, with a focus on how these differences vary by disease onset (early vs. late). : A retrospective cohort study including individuals diagnosed with psoriasis between 1998 and 2022 through Clalit Health Services (CHS) in Israel. Gender-based differences in treatment patterns by psoriasis onset were analyzed using Chi-square and Fisher exact tests and survival analyses. : The disease onset showed a bimodal distribution among 3999 individuals, with women experiencing earlier onset compared to men (median age 37.2 vs. 40.1 years; < 0.001). In early-onset psoriasis, men were significantly more likely than women to receive systemic (17.9% vs. 6.5%; < 0.001) and biological therapies (3.8% vs. 1.6%; = 0.005) and initiated these treatments earlier ( < 0.001). In contrast, no significant gender-based treatment differences were observed in late-onset cases. Regardless of gender, early-onset patients began phototherapy earlier than late-onset patients ( < 0.001). : Our results suggest that disease onset timing may influence treatment decisions and highlight the need for a more personalized approach to psoriasis management that considers both gender and age of onset.
银屑病是一种慢性炎症性皮肤病，其发病分布呈双峰模式，病例分为早发型或晚发型。虽然银屑病在男女中的患病率几乎相等，但男性通常病情更为严重，导致治疗方法和临床结果存在差异。本研究的目的是调查银屑病患者治疗模式的性别差异，重点关注这些差异如何因疾病发作（早发与晚发）而有所不同。：一项回顾性队列研究，纳入了1998年至2022年期间通过以色列克拉利特医疗服务机构（CHS）诊断为银屑病的个体。使用卡方检验、Fisher精确检验和生存分析来分析银屑病发病的治疗模式中的性别差异。：在3999名个体中，疾病发作呈双峰分布，女性发病早于男性（中位年龄37.2岁对40.1岁；<0.001）。在早发型银屑病中，男性接受系统治疗（17.9%对6.5%；<0.001）和生物治疗（3.8%对1.6%；=0.005）的可能性显著高于女性，并更早开始这些治疗（<0.001）。相比之下，在晚发型病例中未观察到显著的基于性别的治疗差异。无论性别如何，早发型患者比晚发型患者更早开始光疗（<0.001）。：我们的结果表明，疾病发作时间可能会影响治疗决策，并强调需要一种更个性化的银屑病管理方法，同时考虑性别和发病年龄。
