Adachi Akimasa, Honda Tetsuya
Department of Dermatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
J Clin Med. 2022 Aug 20;11(16):4890. doi: 10.3390/jcm11164890.
Psoriasis is a common chronic inflammatory skin disease of the interleukin (IL)-23/IL-17 axis. The severity of psoriasis has been reported as higher in men than in women. The immunoregulatory role of female sex hormones has been proposed to be one of the factors responsible for sex differences. Among female sex hormones, estrogens have been suggested to be significantly involved in the development of psoriasis by various epidemiological and in vitro studies. For example, the severity of psoriasis is inversely correlated with serum estrogen levels. In vitro, estrogens suppress the production of psoriasis-related cytokines such as IL-1β and IL-23 from neutrophils and dendritic cells, respectively. Furthermore, a recent study using a mouse psoriasis model indicated the inhibitory role of estrogens in psoriatic dermatitis by suppressing IL-1β production from neutrophils and macrophages. Understanding the role and molecular mechanisms of female sex hormones in psoriasis may lead to better control of the disease.
银屑病是一种常见的、由白细胞介素（IL）-23/IL-17轴介导的慢性炎症性皮肤病。据报道，男性银屑病的严重程度高于女性。女性性激素的免疫调节作用被认为是导致性别差异的因素之一。在女性性激素中，各种流行病学和体外研究表明，雌激素与银屑病的发生发展密切相关。例如，银屑病的严重程度与血清雌激素水平呈负相关。在体外，雌激素分别抑制中性粒细胞和树突状细胞产生银屑病相关细胞因子，如IL-1β和IL-23。此外，最近一项使用小鼠银屑病模型的研究表明，雌激素通过抑制中性粒细胞和巨噬细胞产生IL-1β，对银屑病性皮炎具有抑制作用。了解女性性激素在银屑病中的作用及其分子机制可能有助于更好地控制该疾病。
