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注意力缺陷多动障碍与注意力缺陷障碍的产科结局比较:一项基于人群的研究

Comparing Obstetrical Outcomes Between Attention Deficit Hyperactivity Disorder and Attention Deficit Disorder: A Population-Based Studys.

作者信息

Amikam Uri, Badeghiesh Ahmad, Baghlaf Haitham, Brown Richard, Dahan Michael H

机构信息

Department of Obstetrics and Gynecology, McGill University, Montréal, QC H3A 0G4, Canada.

The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

出版信息

J Clin Med. 2025 Jun 11;14(12):4142. doi: 10.3390/jcm14124142.

Abstract

: Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders affecting women of reproductive age. Previous data on this condition did not study its different symptom clusters separately. Our aim was to compare perinatal outcomes between women with hyperactivity cluster (ADHD) and those with the inattentive cluster (attention deficit disorder (ADD)). : A retrospective population-based study utilizing data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS). All deliveries or maternal deaths from 2004 to 2014 were available for analysis, and perinatal outcomes were compared between participants with an ADD diagnosis and those with an ADHD diagnosis. A multivariate logistic regression was used to control for confounders. : During the study period, there were 9,096,788 deliveries. Of them, 7103 had an ADHD diagnosis, and 2928 had an ADD diagnosis. Women with ADHD, compared to those with ADD, were more likely to be younger than 25 years of age; to be Black; to be from a lower income quartile; to smoke tobacco during pregnancy; and to use illicit drugs ( < 0.001 for all). Using multivariate logistic regression, women with ADHD, compared to those with ADD, had a higher rate of hypertensive disorders of pregnancy (HDPs) (aOR 1.19, 95% CI 1.03-1.37, = 0.02), preterm delivery (aOR 1.19, 95% CI 1.01-1.39, = 0.038), maternal infection (aOR 1.39, 95% CI 1.04-1.85, = 0.024), and small-for-gestational-age (SGA) neonates (aOR 1.33, 95% CI 1.04-1.69, = 0.022). : Women with an ADHD diagnosis, compared to those with ADD, had a higher incidence of various maternal and neonatal complications, including HDPs, preterm delivery, and SGA neonates.

摘要

注意缺陷多动障碍(ADHD)是影响育龄女性的最常见神经发育障碍之一。此前关于这种疾病的数据并未分别研究其不同的症状群。我们的目的是比较患有多动症状群(ADHD)的女性和患有注意力不集中症状群(注意力缺陷障碍(ADD))的女性的围产期结局。

一项基于人群的回顾性研究,利用医疗保健成本与利用项目-全国住院患者样本(HCUP-NIS)的数据。分析了2004年至2014年期间所有的分娩或孕产妇死亡情况,并比较了诊断为ADD的参与者和诊断为ADHD的参与者的围产期结局。采用多因素逻辑回归来控制混杂因素。

在研究期间,共有9,096,788例分娩。其中,7103例被诊断为ADHD,2928例被诊断为ADD。与患有ADD的女性相比,患有ADHD的女性更可能年龄小于25岁;为黑人;来自收入较低的四分位数;在孕期吸烟;以及使用非法药物(所有比较P<0.001)。使用多因素逻辑回归分析,与患有ADD的女性相比,患有ADHD的女性发生妊娠高血压疾病(HDPs)的几率更高(调整后比值比[aOR]为1.19,95%置信区间[CI]为1.03-1.37,P = 0.02)、早产(aOR为1.19,95%CI为1.01-1.39,P = 0.038)、孕产妇感染(aOR为1.39,95%CI为1.04-1.85,P = 0.024)以及小于胎龄(SGA)新生儿(aOR为1.

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本文引用的文献

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Attention-deficit/hyperactivity disorder.注意缺陷多动障碍。
Nat Rev Dis Primers. 2024 Feb 22;10(1):11. doi: 10.1038/s41572-024-00495-0.
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Obstetric complications in mothers with ADHD.患有注意力缺陷多动障碍(ADHD)的母亲的产科并发症。
Front Reprod Health. 2022 Nov 7;4:1040824. doi: 10.3389/frph.2022.1040824. eCollection 2022.
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Parental ADHD in pregnancy and the postpartum period - A systematic review.妊娠期和产后父母注意缺陷多动障碍 - 系统评价。
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