Mahoney Alessia, D'Angelo Arianna
School of Medicine, Cardiff University, Cardiff CF14 4YS, UK.
Life (Basel). 2025 May 27;15(6):863. doi: 10.3390/life15060863.
Polycystic ovary syndrome (PCOS) is the expression of a complex alteration of the reproductive system. It is characterised by the increase in androgens, causing symptoms such as hirsutism, as well as infertility in many. This paper reviews whether Clomiphene Citrate, Letrozole and Inositol function better as monotherapy or combined therapy for anovulatory infertile PCOS patients. Ovulation and pregnancy rate were used as primary outcomes. PubMed and Scopus were the search engines of choice. Papers were excluded if patients were undertaking other fertility interventions, overlapping populations and non-RCT papers. It was found that co-prescribing Letrozole or Clomiphene Citrate alongside Metformin should be considered, Inositol should be examined as an alternative insulin sensitiser to Metformin and studies should be undertaken to identify the ideal dose and duration of Inositol therapy. Further large, well-designed, multi-centre studies should be conducted to solidify the claims of this review.
多囊卵巢综合征（PCOS）是生殖系统复杂改变的一种表现。其特征为雄激素增加，会导致多毛等症状，且许多患者会出现不孕。本文综述了枸橼酸氯米芬、来曲唑和肌醇作为单一疗法或联合疗法治疗无排卵性不孕PCOS患者时哪种效果更佳。排卵率和妊娠率被用作主要观察指标。PubMed和Scopus是首选的搜索引擎。如果患者正在接受其他生育干预、研究人群重叠或为非随机对照试验论文，则将其排除。研究发现，应考虑将二甲双胍与来曲唑或枸橼酸氯米芬联合使用，应研究肌醇作为二甲双胍替代胰岛素增敏剂的效果，还应开展研究以确定肌醇治疗的理想剂量和疗程。应进一步开展大型、设计良好的多中心研究，以证实本综述的观点。
