Gambioli Riccardo, Forte Gianpiero, Buzzaccarini Giovanni, Unfer Vittorio, Laganà Antonio Simone
R&D Department, Lo.Li. Pharma, 00156 Rome, Italy.
Unit of Gynecology and Obstetrics, Department of Women and Children's Health, University of Padua, 35128 Padua, Italy.
Pharmaceuticals (Basel). 2021 May 25;14(6):504. doi: 10.3390/ph14060504.
Pregnancy is a complex process, featuring several necessary changes in women's physiology. Most women undergo healthy pregnancies; even so, several women experience reduced fertility or pathologies related to the pregnancy. In the last years, researchers investigated several molecules as promoters of fertility. Among all, myo-inositol (myo-ins) represents a safe compound that proved useful in issues related to fertility and pregnancy. In fact, myo-ins participates in several signaling processes, including the pathways of insulin and gonadotropins, and, therefore, it is likely to positively affect fertility. In particular, several clinical trials demonstrate that its administration can have therapeutic effects in infertile women, and that it can also be useful as a preventive treatment during pregnancy. Particularly, myo-ins could prevent the onset of neural tube defects and the occurrence of gestational diabetes mellitus, promoting a trouble-free gestation. Due to the safety and efficiency of myo-ins, such a treatment may also substitute several pharmaceuticals, which are contraindicated in pregnancy.
怀孕是一个复杂的过程，女性生理会发生一些必要的变化。大多数女性经历健康的怀孕过程；即便如此，仍有一些女性生育能力下降或出现与怀孕相关的病症。近年来，研究人员研究了多种作为生育促进剂的分子。其中，肌醇是一种安全的化合物，已证明对生育和怀孕相关问题有用。事实上，肌醇参与多种信号传导过程，包括胰岛素和促性腺激素途径，因此，它可能对生育能力产生积极影响。特别是，多项临床试验表明，给予肌醇对不孕女性有治疗作用，并且在孕期作为预防性治疗也可能有用。具体而言，肌醇可以预防神经管缺陷的发生和妊娠期糖尿病的出现，促进孕期顺利。由于肌醇的安全性和有效性，这种治疗也可能替代几种孕期禁忌的药物。
