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基于CT血管造影图像的ConvMixer分类器对冠状动脉疾病进行分类。

Coronary artery disease classification using ConvMixer based classifier from CT angiography images.

作者信息

Rajeev C, Natarajan Karthika

机构信息

School of Computer Science and Engineering, VIT-AP University, Amaravati, Andhra Pradesh, India.

出版信息

PeerJ Comput Sci. 2025 Mar 27;11:e2771. doi: 10.7717/peerj-cs.2771. eCollection 2025.

Abstract

Coronary artery disease (CAD) has recently emerged as a predominant source of morbidity and death worldwide. Assessing the existence and severity of CAD in people is crucial for determining the optimal treatment strategy. Currently, computed tomography (CT) delivers excellent spatial resolution pictures of the heart and coronary arteries at a rapid pace. Conversely, several problems exist in the analysis of cardiac CT images for indications of CAD. Research investigations employ machine learning (ML) and deep learning (DL) techniques to achieve high accuracy and consistent performance, hence addressing existing restrictions. This research proposes convMixer with median filter and morphological operations for the classification of the coronary artery disease from computed tomography angiography images. A total of 5,959 CT angiography images were used for classification. The model achieved an accuracy of 96.30%, sensitivity of 94.39%, and specificity of 99.16% for combination of the morphological operations and convMixer, 88.92% of accuracy and 89.56% of sensitivity, and 93.10% of specificity for the combination of median filter and convMixer and 94.63% of accuracy, 95.82% of sensitivity, and 93.10% of specificity for convMixer. The findings indicate the viability of automated non-invasive identification of individuals necessitating invasive coronary angiography images and maybe future coronary artery operations. This may potentially decrease the number of people who receive invasive coronary angiography images. Lastly, post-image analysis was conducted using DL heat maps to understand the decisions made by the proposed model. The proposed integrated DL intelligent system enhances the efficiency of illness diagnosis, reduces manual involvement in diagnostic processes, supports medical professionals in diagnostic decision-making, and offers supplementary techniques for future medical diagnostic systems based on coronary angioplasty.

摘要

冠状动脉疾病(CAD)最近已成为全球发病和死亡的主要原因。评估人群中CAD的存在和严重程度对于确定最佳治疗策略至关重要。目前,计算机断层扫描(CT)能够快速提供心脏和冠状动脉的高空间分辨率图像。相反,在分析心脏CT图像以判断CAD迹象方面存在若干问题。研究调查采用机器学习(ML)和深度学习(DL)技术来实现高精度和一致的性能,从而解决现有限制。本研究提出了带有中值滤波器和形态学操作的convMixer,用于从计算机断层扫描血管造影图像中对冠状动脉疾病进行分类。总共5959张CT血管造影图像用于分类。对于形态学操作和convMixer的组合,该模型的准确率为96.30%,灵敏度为94.39%,特异性为99.16%;对于中值滤波器和convMixer的组合,准确率为88.92%,灵敏度为89.56%,特异性为93.10%;对于convMixer,准确率为94.63%,灵敏度为95.82%,特异性为93.10%。研究结果表明,自动无创识别需要进行有创冠状动脉造影图像检查及可能未来进行冠状动脉手术的个体是可行的。这可能会减少接受有创冠状动脉造影图像检查的人数。最后,使用DL热图进行图像后分析,以了解所提出模型做出的决策。所提出的集成DL智能系统提高了疾病诊断效率,减少了诊断过程中的人工参与,支持医学专业人员进行诊断决策,并为基于冠状动脉成形术的未来医学诊断系统提供了补充技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2b/12190484/ce121ba7197a/peerj-cs-11-2771-g001.jpg

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