Celik Burak, Kaya Merve, Saraç Gulhan A, Aksoy Hakan
Internal Medicine, Cook County Health, Chicago, USA.
Dermatology, Health Sciences University, Ankara Bilkent City Hospital, Ankara, TUR.
Cureus. 2025 May 26;17(5):e84835. doi: 10.7759/cureus.84835. eCollection 2025 May.
Lichen planopilaris (LPP) is a chronic cicatricial alopecia characterized by lymphocytic inflammation leading to permanent hair follicle destruction. It is associated with several systemic conditions, including hypothyroidism, dyslipidemia, hypertension, and an increased risk for cardiovascular disease. This study aims to investigate the relationship between serum lipid parameters and atherogenic indexes to evaluate the cardiovascular risk status in patients with LPP.
This retrospective study was conducted with 115 LPP patients and 115 healthy controls without LPP. Serum total cholesterol, triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were retrieved from hospital records. Atherogenic Index of Plasma (AIP), Castelli Risk Index (CRI) I and II, and Atherogenic Coefficient (AC) were calculated based on lipid profiles.
LPP patients had significantly higher serum TG, total cholesterol, LDL, non-HDL cholesterol, CRI-I, CRI-II, and AC. Additionally, LPP patients were more likely to fall into the high-risk category for CRI-I, CRI-II, and AC.
Our study shows that patients with LPP have a higher pro-atherogenic lipid profile and atherogenic indexes. Systemic inflammation and peroxisome proliferator-activated receptor signaling dysregulation may underlie this association, necessitating closer cardiovascular and lipid monitoring in LPP patients.
扁平苔藓型毛发扁平苔藓（LPP）是一种慢性瘢痕性脱发，其特征为淋巴细胞炎症导致永久性毛囊破坏。它与多种全身性疾病相关，包括甲状腺功能减退、血脂异常、高血压以及心血管疾病风险增加。本研究旨在探讨血清脂质参数与致动脉粥样硬化指数之间的关系，以评估LPP患者的心血管风险状况。
本回顾性研究纳入了115例LPP患者和115例无LPP的健康对照。从医院记录中获取血清总胆固醇、甘油三酯（TG）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。根据血脂谱计算血浆致动脉粥样硬化指数（AIP）、卡斯泰利风险指数（CRI）I和II以及致动脉粥样硬化系数（AC）。
LPP患者的血清TG、总胆固醇、LDL、非HDL胆固醇、CRI-I、CRI-II和AC显著更高。此外，LPP患者更有可能属于CRI-I、CRI-II和AC的高风险类别。
我们的研究表明，LPP患者具有更高的促动脉粥样硬化血脂谱和致动脉粥样硬化指数。全身炎症和过氧化物酶体增殖物激活受体信号失调可能是这种关联的基础，因此有必要对LPP患者进行更密切的心血管和血脂监测。
