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Fetal-hemoglobin-expressing red blood cells ("F cells") consist of three distinct types as revealed by single-cell transcriptomic analysis of circulating reticulocytes.

作者信息

Rooks Helen, Ng Cecilia, Oikonomopoulos Spyros, Hoss Sara El, Turner Charles, Kong Kar Lok, Mian Syed, Daniel Yvonne, Ojewunmi Oyesola O, Brewin John, Rees David, Mufti Ghulam J, Ragoussis Jiannis, Strouboulis John, Menzel Stephan

机构信息

Red Cell Haematology School of Cancer and Pharmaceutical Sciences, Comprehensive Cancer Centre, King's College London London UK.

Department of Human Genetics, McGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine McGill University Montreal Québec Canada.

出版信息

Hemasphere. 2025 Jun 25;9(6):e70174. doi: 10.1002/hem3.70174. eCollection 2025 Jun.

DOI:10.1002/hem3.70174
PMID:40568351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12194718/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d342/12194718/bcbd222a2eeb/HEM3-9-e70174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d342/12194718/4e9cbe60c202/HEM3-9-e70174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d342/12194718/bcbd222a2eeb/HEM3-9-e70174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d342/12194718/4e9cbe60c202/HEM3-9-e70174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d342/12194718/bcbd222a2eeb/HEM3-9-e70174-g001.jpg

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1
Fetal-hemoglobin-expressing red blood cells ("F cells") consist of three distinct types as revealed by single-cell transcriptomic analysis of circulating reticulocytes.通过对循环网织红细胞的单细胞转录组分析发现，表达胎儿血红蛋白的红细胞（“F细胞”）由三种不同类型组成。
Hemasphere. 2025 Jun 25;9(6):e70174. doi: 10.1002/hem3.70174. eCollection 2025 Jun.
2
Enumeration of Fetal Red Blood Cells, Hemoglobin-Specific RBC Cells, and F Reticulocytes in Human Blood.人血中胎儿红细胞、血红蛋白特异性红细胞及F网织红细胞的计数
Curr Protoc Cytom. 2019 Sep;90(1):e56. doi: 10.1002/cpcy.56.
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Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes.镰状细胞贫血网织红细胞和双凹圆盘状红细胞亚群中钾氯共转运驱动的红细胞密度快速增加。
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Technical Report: Triple-Colour Staining Flow Cytometry for Co-Distribution of Thrombospondin Receptor (CD36), Ribonucleic Acid (RNA) and Fetal Haemoglobin (HbF) in Sickle Red Blood Cells.技术报告：镰状红细胞中血小板反应蛋白受体（CD36）、核糖核酸（RNA）和胎儿血红蛋白（HbF）共分布的三色染色流式细胞术
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F reticulocytes assay: a method to evaluate fetal hemoglobin production.网织红细胞检测：一种评估胎儿血红蛋白生成的方法。
Hemoglobin. 1998 Sep-Nov;22(5-6):419-25. doi: 10.3109/03630269809071540.
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The percentages of Hb F and of G gamma and A gamma chains in the Hb F synthesized by reticulocytes and BFUe-derived colonies of patients with sickle cell anemia.镰状细胞贫血患者网织红细胞和BFUe来源集落合成的Hb F中Hb F、Gγ链和Aγ链的百分比。
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Definitive estimate of rate of hemoglobin switching: measurement of percent hemoglobin F in neonatal reticulocytes.血红蛋白转换率的确定性估计：新生儿网织红细胞中血红蛋白F百分比的测量。
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Microscopic method for assaying F cell production: illustrative changes during infancy and in aplastic anemia.用于测定F细胞生成的显微镜方法：婴儿期及再生障碍性贫血中的典型变化。
Blood. 1978 Oct;52(4):664-72.
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Treatment of sickle cell anemia with hydroxyurea and erythropoietin.用羟基脲和促红细胞生成素治疗镰状细胞贫血。
N Engl J Med. 1990 Aug 9;323(6):366-72. doi: 10.1056/NEJM199008093230602.
10
Survival of F-reticulocytes in sickle cell disease.镰状细胞病中F-网织红细胞的存活情况。
Biochem Biophys Res Commun. 1995 Dec 26;217(3):924-30. doi: 10.1006/bbrc.1995.2859.

本文引用的文献

1
The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution.单细胞分辨率下正常和无效红细胞生成的转录组景观。
Blood Adv. 2023 Sep 12;7(17):4848-4868. doi: 10.1182/bloodadvances.2023010382.
2
Single Cell RNA-Seq Analysis of Human Red Cells.人类红细胞的单细胞RNA测序分析
Front Physiol. 2022 Apr 20;13:828700. doi: 10.3389/fphys.2022.828700. eCollection 2022.
3
Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease.胎儿血红蛋白可挽救镰状细胞病无效的红细胞生成。
Haematologica. 2021 Oct 1;106(10):2707-2719. doi: 10.3324/haematol.2020.265462.
4
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.通过对人类 BM 和 UCB 细胞的单细胞转录组分析揭示的红系分化连续体的假定调节因子。
Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12868-12876. doi: 10.1073/pnas.1915085117. Epub 2020 May 26.
5
Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.通过比较 F 和 A 红细胞来理解胎儿血红蛋白诱导的异质性。
Blood. 2020 May 28;135(22):1957-1968. doi: 10.1182/blood.2020005058.
6
Comparing the two leading erythroid lines BEL-A and HUDEP-2.比较两种主要的红系细胞系BEL-A和HUDEP-2。
Haematologica. 2020 Aug;105(8):e389-e394. doi: 10.3324/haematol.2019.229211. Epub 2019 Nov 21.
7
Fetal γ-globin genes are regulated by the long noncoding RNA locus.胎儿 γ-珠蛋白基因受长链非编码 RNA 基因座调控。
Blood. 2018 Nov 1;132(18):1963-1973. doi: 10.1182/blood-2018-07-862003. Epub 2018 Aug 27.
8
Control of globin gene expression during development and erythroid differentiation.发育和红细胞分化过程中珠蛋白基因表达的调控。
Exp Hematol. 2005 Mar;33(3):259-71. doi: 10.1016/j.exphem.2004.11.007.
9
Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited.珠蛋白基因表达中的随机模式在转录激活之前就已建立，并且是克隆遗传的。
Mol Cell. 2002 Jun;9(6):1319-26. doi: 10.1016/s1097-2765(02)00558-0.
10
Differential regulation of A gamma and G gamma fetal hemoglobin mRNA levels by hydroxyurea and butyrate.羟基脲和丁酸盐对胎儿血红蛋白Aγ和Gγ mRNA水平的差异调节
Exp Hematol. 1998 Mar;26(3):265-72.