Hu Hang, Li Kui, Jin Zhidong, Wang Kaijin, Liu Bicui
Bishan Hospital of Chongqing Medical University, Chongqing, China.
Front Cell Infect Microbiol. 2025 Jun 11;15:1590220. doi: 10.3389/fcimb.2025.1590220. eCollection 2025.
Pulmonary abscess is a serious infectious disease characterized by localized lung tissue necrosis, primarily caused by anaerobic or facultative anaerobic bacterial infections. While the (SAG) is a well-established pathogen in pulmonary abscess formation, recent findings suggest that strict anaerobes such as and can also contribute to deep-seated infections. However, their role in rapidly progressive pulmonary abscesses has not been previously documented. Here, we present a case of a rapidly progressive pulmonary abscess caused by and in an immunocompetent patient, initially misdiagnosed as lung cancer. This case highlights the importance of differentiating infectious lung lesions from malignancies and underscores the clinical utility of metagenomic next-generation sequencing (mNGS) in diagnosing rare anaerobic infections, offering valuable insights for precise diagnostic and therapeutic strategies.
肺脓肿是一种严重的感染性疾病，其特征为局部肺组织坏死，主要由厌氧或兼性厌氧细菌感染引起。虽然 [此处原文缺失具体细菌名称] 是肺脓肿形成中一种公认的病原体，但最近的研究结果表明，诸如 [此处原文缺失具体细菌名称] 和 [此处原文缺失具体细菌名称] 等严格厌氧菌也可导致深部感染。然而，它们在快速进展性肺脓肿中的作用此前尚未见报道。在此，我们报告一例免疫功能正常的患者由 [此处原文缺失具体细菌名称] 和 [此处原文缺失具体细菌名称] 引起的快速进展性肺脓肿病例，该病例最初被误诊为肺癌。本病例强调了区分感染性肺部病变与恶性肿瘤的重要性，并突出了宏基因组下一代测序（mNGS）在诊断罕见厌氧感染中的临床实用性，为精确的诊断和治疗策略提供了有价值的见解。
