The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Public Health. 2024 Feb 8;11:1307902. doi: 10.3389/fpubh.2023.1307902. eCollection 2023.
(), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for -related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to , drawing insights from an extensive literature review of pertinent case reports.
A 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient's symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to . Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where was identified as the causative agent.
The literature analysis underscores the predilection of for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of -associated infections.
（）是一种革兰氏阳性厌氧菌，具有在口腔黏膜和皮肤表面定植的倾向，可能演变为与多种疾病相关的致病实体。与相关疾病的诊断轨迹存在延迟，通常会产生严重后果，包括死亡，这归因于缺乏症状特异性和培养方面的挑战。缺乏针对 加剧相关疾病处理复杂性的共识。本研究旨在通过对相关病例报告的广泛文献回顾，阐明和仔细研究与 相关的临床表现。
一名 53 岁男性因反复咯血到我院就诊。在等待病原体培养结果的同时开始进行经验性治疗，但患者的症状持续存在。随后进行的宏基因组下一代测序（mNGS）分析显示，该患者患有由 引起的肺部感染。在使用哌拉西林舒巴坦钠和莫西沙星盐酸盐治疗后，症状得到缓解。利用 PubMed 数据库进行了全面的文献回顾，以评估过去十年中被确定为致病因子的病例报告。
文献分析强调了 偏爱患有心血管疾病、糖尿病、骨科疾病和肿瘤的免疫功能低下人群。包括口腔和牙周卫生、吸烟和饮酒在内的危险因素与 感染有关。临床表现包括发热、咳嗽、咳痰和背痛，可能导致严重后果，如 Spondylodiscitis、化脓性关节炎、肺脓肿、菌血症、败血症和死亡。虽然传统的细菌培养仍然是主要的诊断工具，但像 mNGS 这样的新兴技术提供了替代考虑。在治疗方式方面，β-内酰胺类抗生素和硝基咪唑类药物占主导地位，分别有 56.10%（46/82）和 23.17%（19/82）的患者恢复。本病例报告和文献回顾旨在提高临床医生和实验室医学专业人员对与相关感染相关的复杂性的认识。
