Joseph Jocelyn Anna, Pujari Vishwanath Vasant
Department of Respiratory Medicine, New Cross Hospital, Wolverhampton, United Kingdom.
Department of Respiratory Medicine, Government Medical College, Jalgaon, Maharashtra, India.
Lung India. 2025 Jul 1;42(4):343-346. doi: 10.4103/lungindia.lungindia_633_24. Epub 2025 Jun 27.
Chronic obstructive pulmonary disease (COPD) is a significant global health concern, projected to be the fourth leading cause of death by 2030. This study explores the correlation between the COPD assessment test (CAT) score, history of exacerbations, and the BODE Index in stable COPD patients. While the BODE Index is a validated multidimensional grading system, its application in outpatient settings, especially in resource-constrained setting, can be challenging due to the need for spirometry.
We conducted a cross sectional, observational study. It was conducted over 18 months in Mumbai and recruited 50 stable COPD patients. The CAT score and history of exacerbations in the previous year were evaluated alongside the BODE Index and other demographic data.
The correlation between quantitative variables was performed using Pearson and Spearman's correlation coefficient, with P < 0.05 considered statistically significant.
In the study population, the mean rate of exacerbation observed was 1.52 (SD = 2.279)/person/year, and the mean CAT score was 9.88 ± 7.34 (range: 0-27). The median BODE Index was 3 with most of the patients 44% (n = 22) having a BODE score falling in the first quartile. Positive correlations r (Pearson's) =0.468 (P = 0.000614) and σ (Spearman's) =0.2797 (P = 0.0490) were observed between CAT score with BODE Index and exacerbation history and BODE Index, respectively, indicating a moderate positive correlation between CAT score and BODE Index and statistically significant, albeit weak, correlation with exacerbation history.
Our findings suggest that simple tools like CAT and exacerbation history can be used as surrogates for the BODE Index.
慢性阻塞性肺疾病（COPD）是一个重大的全球健康问题，预计到2030年将成为第四大死因。本研究探讨稳定期COPD患者的COPD评估测试（CAT）评分、急性加重病史与BODE指数之间的相关性。虽然BODE指数是一个经过验证的多维分级系统，但由于需要进行肺功能测定，其在门诊环境中的应用，尤其是在资源有限的环境中，可能具有挑战性。
我们进行了一项横断面观察性研究。该研究在孟买进行了18个月，招募了50例稳定期COPD患者。评估了CAT评分、上一年的急性加重病史以及BODE指数和其他人口统计学数据。
使用Pearson和Spearman相关系数对定量变量之间的相关性进行分析，P < 0.05被认为具有统计学意义。
在研究人群中，观察到的平均急性加重率为1.52（标准差 = 2.279）/人/年，平均CAT评分为9.88 ± 7.34（范围：0 - 27）。BODE指数的中位数为3，大多数患者（44%，n = 22）的BODE评分处于第一四分位数。分别观察到CAT评分与BODE指数之间的正相关r（Pearson相关系数）= 0.468（P = 0.000614）以及急性加重病史与BODE指数之间的正相关σ（Spearman相关系数）= 0.2797（P = 0.0490），表明CAT评分与BODE指数之间存在中度正相关，与急性加重病史存在统计学意义上的弱相关。
我们的研究结果表明，像CAT和急性加重病史这样的简单工具可以用作BODE指数的替代指标。
