Pavuk Marian, Adgate John L, Bartell Scott M, Bell Erin, Brown Linda M, Laumbach Robert J, Schaider Laurel A, van T' Erve Thomas J, Bailey Jordan M, Botelho Julianne Cook, Calafat Antonia M, Cutler Chris R, Forand Steven, Graber Judith M, James-Todd Tamarra, Jeddy Zuha, Kato Kayoko, Mowry Nayara, Nair Anil S, Ohman-Strickland Pamela, Rago Patrick, Schaefer Adam M, Starling Anne P, Vieira Veronica M, Weems Meghan M, Wiant Kristine F, Bove Frank J
Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, USA.
Colorado School of Public Health. University of Colorado Anschutz Campus, Aurora, CO, USA.
Environ Int. 2025 Aug;202:109589. doi: 10.1016/j.envint.2025.109589. Epub 2025 Jun 12.
A nationwide cross-sectional study led by the Agency for Toxic Substances and Disease Registry in collaboration with research and community partners, was designed to investigate health outcomes linked to per- and polyfluoroalkyl substances (PFAS) exposure among residents of communities with contaminated drinking water. The objective was to describe the study design, methods, participant demographics, and PFAS serum concentrations. From 2019 to 2023, adult (18+) and child (ages 4-17) participants were recruited from communities with past or ongoing PFAS contamination of drinking water across eight sites in California, Colorado, Massachusetts, Michigan, New Hampshire, New York, New Jersey, and Pennsylvania. Data on demographics, lifestyle factors, and residential, occupational, and medical history were collected via questionnaires. Extensive clinical tests assessed cardiometabolic, liver, thyroid, kidney, glycemic, and immune parameters. Neurobehavioral tests were administered to children (ages 5-17). PFAS quantified in serum included MeFOSAA, PFHxS, PFOS, PFOA, PFNA, PFDA, and PFUnDA. Serum, whole blood, and urine samples were banked for future analyses. The study enrolled 5826 adults (geometric mean age: 53.6 years; 60.2 % female; 77.2 % non-Hispanic White) and 710 children (geometric mean age: 10.7 years; 48.5 % female; 69 % non-Hispanic White). Compared with NHANES data (2017-2020), adults showed elevated geometric mean concentrations of PFHxS and PFOA; only PFHxS was elevated in children. These serum concentrations reflect a wide range of PFAS exposures in communities affected by contamination from firefighting activities and industrial emissions, and other sources. This large study is a valuable resource for exploring associations between PFAS exposure and health effects in adults and children.
由有毒物质和疾病登记局牵头，与研究和社区合作伙伴合作开展的一项全国性横断面研究，旨在调查受污染饮用水社区居民中与全氟和多氟烷基物质（PFAS）接触相关的健康结果。其目的是描述研究设计、方法、参与者人口统计学特征以及PFAS血清浓度。2019年至2023年期间，从加利福尼亚州、科罗拉多州、马萨诸塞州、密歇根州、新罕布什尔州、纽约州、新泽西州和宾夕法尼亚州的八个地点，招募了有饮用水过去或正在遭受PFAS污染的社区中的成年（18岁及以上）和儿童（4至17岁）参与者。通过问卷收集了人口统计学、生活方式因素以及居住、职业和病史等数据。广泛的临床测试评估了心脏代谢、肝脏、甲状腺、肾脏、血糖和免疫参数。对儿童（5至17岁）进行了神经行为测试。血清中定量的PFAS包括MeFOSAA、PFHxS、PFOS、PFOA、PFNA、PFDA和PFUnDA。血清、全血和尿液样本被储存起来以供未来分析。该研究招募了5826名成年人（几何平均年龄：53.6岁；60.2%为女性；77.2%为非西班牙裔白人）和710名儿童（几何平均年龄：10.7岁；48.5%为女性；69%为非西班牙裔白人）。与美国国家健康与营养检查调查（NHANES）数据（2017 - 2020年）相比，成年人的PFHxS和PFOA几何平均浓度升高；儿童中仅PFHxS升高。这些血清浓度反映了受消防活动和工业排放及其他来源污染影响的社区中广泛的PFAS暴露情况。这项大型研究是探索PFAS暴露与成人和儿童健康影响之间关联的宝贵资源。
