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Targeting dementia prevention with semaglutide: The case for APOE4 homozygotes.

作者信息

Daly Timothy, Imbimbo Bruno P

机构信息

UMR 1219 Bordeaux Population Health, Université de Bordeaux & INSERM, Bordeaux, France.

UMR 5164, ImmunoConcept, University of Bordeaux & CNRS, Bordeaux, France.

出版信息

Alzheimers Dement. 2025 Jun;21(6):e70422. doi: 10.1002/alz.70422.

Abstract
摘要

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本文引用的文献

1
APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults.
JAMA Netw Open. 2025 May 1;8(5):e258903. doi: 10.1001/jamanetworkopen.2025.8903.
2
The Risk of Alzheimer Disease in APOE4 Homozygotes.
JAMA Neurol. 2025 Apr 14. doi: 10.1001/jamaneurol.2025.0639.
3
Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis.
JAMA Neurol. 2025 May 1;82(5):450-460. doi: 10.1001/jamaneurol.2025.0360.
4
GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias.
JAMA Neurol. 2025 May 1;82(5):439-449. doi: 10.1001/jamaneurol.2025.0353.
6
Analysis of semaglutide's effect on Alzheimer's disease risk.
Alzheimers Dement. 2025 Feb;21(2):e14462. doi: 10.1002/alz.14462. Epub 2024 Dec 31.
8
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.
Alzheimers Dement. 2024 Aug;20(8):5143-5169. doi: 10.1002/alz.13859. Epub 2024 Jun 27.
9
Testing the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease.
Alzheimers Dement. 2022 Dec;18(12):2687-2698. doi: 10.1002/alz.12624. Epub 2022 Feb 24.

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