Hong Bo, Qiu Ling, Lv Ruo, Yu Zongxia
Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China.
College of Life Science, Nanchang University, Nanchang 330031, China.
Microorganisms. 2025 Jun 10;13(6):1342. doi: 10.3390/microorganisms13061342.
Terpenoids, which are widely distributed in nature, possess diverse biological activities, physiological functions, and economic values. They are extensively exploited by plants and microorganisms. However, the abundance of terpenoids in natural hosts is extremely low, making it difficult to meet the market demands. In recent years, along with the advancement of metabolic engineering and synthetic biology, it has become feasible for microorganisms to produce exogenous terpenoids sustainably. Cyanobacteria and other photosynthetic microorganisms have attracted growing attention due to their capacity to produce terpenoids by harnessing light and carbon dioxide. In this article, we comprehensively summarize the biosynthetic pathways of terpenoids and the progress in utilizing cyanobacteria as chassis for the production of terpenoids, and further discuss strategies for augmenting the yields of terpenoids.
萜类化合物广泛分布于自然界，具有多种生物活性、生理功能和经济价值。它们被植物和微生物大量利用。然而，天然宿主中萜类化合物的含量极低，难以满足市场需求。近年来，随着代谢工程和合成生物学的发展，微生物可持续生产外源萜类化合物已成为可能。蓝细菌和其他光合微生物因其能够利用光和二氧化碳生产萜类化合物而受到越来越多的关注。在本文中，我们全面总结了萜类化合物的生物合成途径以及利用蓝细菌作为底盘生产萜类化合物的进展，并进一步讨论了提高萜类化合物产量的策略。
