Köppel C, Arndt I, Arendt U, Koeppe P
J Toxicol Clin Toxicol. 1985;23(2-3):103-15. doi: 10.3109/15563658508990621.
After ingestion of 12-16 g tetrachloroethylene, a 6-year-old boy was admitted to the clinic in coma. In view of the high initial tetrachloroethylene blood level, hyperventilation therapy was performed. Under this therapeutic regimen, the clinical condition of the patient improved considerably. The tetrachloroethylene blood level profile which was determined under hyperventilation therapy could be computer-fitted to a two-compartment model. Elimination of tetrachloroethylene from the blood compartment occurred via a rapid and a slow process with half-lives of 30 min and 36 hours, respectively. These values compared favourably with the half-lives of 160 min and 33 hours under normal respiratory conditions. During hyperventilation therapy, the relative contribution to the fast elimination process increased from 70% for physiological minute volume to 99.9%. A minor fraction of the ingested dose was excreted with the urine (integral of 1% during the first 3 days). In contrast to previous results, trace amounts of unchanged tetrachloroethylene were detected in the urine besides trichloroacetic acid and trichloroethanol.
一名6岁男童摄入12 - 16克四氯乙烯后，昏迷状态下被送往诊所。鉴于初始血液中四氯乙烯水平较高，遂进行了过度通气疗法。在该治疗方案下，患者的临床状况有了显著改善。在过度通气疗法下测定的四氯乙烯血液水平曲线可以用双室模型进行计算机拟合。血液中四氯乙烯的消除通过快速和缓慢两个过程进行，半衰期分别为30分钟和36小时。这些数值与正常呼吸条件下160分钟和33小时的半衰期相比更具优势。在过度通气疗法期间，快速消除过程的相对贡献从生理分钟通气量时的70%增加到了99.9%。摄入剂量的一小部分随尿液排出（头3天累计为1%）。与之前的结果不同，除了三氯乙酸和三氯乙醇外，尿液中还检测到了痕量未变化的四氯乙烯。
