Köppel C, Lanz H J, Ibe K
Reanimationszentrum, Klinikum Charlottenburg, Freie Universität Berlin.
Intensive Care Med. 1988;14(1):74-6. doi: 10.1007/BF00254128.
One hour after suicidal ingestion of about 150 g of trichloroethylene, a 32-year-old male was admitted to hospital. On admission, the patient's state of consciousness deteriorated from somnolence to coma. Based on blood level data, an absorbed trichloroethylene dose of at least 35 g was estimated. Additionally, ethanol, which is a strong inhibitor of trichloroethylene metabolism, had been ingested. With respect to the high dose of trichloroethylene, hyperventilation therapy was performed for 28 h. Concentrations of trichloroethylene and its metabolites in blood and urine were determined by gas chromatography. Due to hyperventilation and inhibition of trichloroethylene metabolism, not more than 30% of the absorbed dose was metabolized and excreted via kidneys. Under normal respiratory conditions and in the absence of ethanol, this fraction amounts to about 75%. Obviously, hyperventilation and ethanol-induced inhibition of metabolism led to considerably enforced pulmonary elimination of the absorbed trichloroethylene.
一名32岁男性在自杀性摄入约150克三氯乙烯1小时后入院。入院时，患者意识状态从嗜睡恶化为昏迷。根据血药浓度数据，估计吸收的三氯乙烯剂量至少为35克。此外，患者还摄入了乙醇，乙醇是三氯乙烯代谢的强效抑制剂。鉴于三氯乙烯剂量较高，进行了28小时的过度通气治疗。采用气相色谱法测定血液和尿液中三氯乙烯及其代谢物的浓度。由于过度通气和三氯乙烯代谢受到抑制，经肾脏代谢和排泄的吸收剂量不超过30%。在正常呼吸条件下且无乙醇存在时，该比例约为75%。显然，过度通气和乙醇诱导的代谢抑制导致吸收的三氯乙烯经肺部排泄显著增加。
