Adler M, Hawke M, Berger G, Harwood A
J Otolaryngol. 1985 Aug;14(4):226-32.
Radiation is used to treat many head and neck tumors, and of necessity the temporal bone is sometimes included in the paths of radiation. We studied the histopathology of the external auditory canal in 13 temporal bones from 10 patients who had undergone irradiation for head and neck tumors. The pathologic changes noted could be divided into: bony changes, and soft tissue changes. Bony changes manifested were those of resorption, fibrosis, empty lacunae, and sequestration. There were five soft tissue changes: the formation of a secondary cholesteatoma, ulceration of the lining epithelium with resorption of the underlying bone, thickened epithelium in the canal as well as in the tympanic membrane, subepithelial fibrosis, and atrophic ceruminous glands. Clinically these changes can be manifested as a persistent otitis externa, with otorrhea and otalgia.
放射治疗被用于治疗许多头颈部肿瘤，颞骨有时不可避免地会被纳入放射路径。我们研究了10例接受过头颈部肿瘤放疗的患者的13块颞骨的外耳道组织病理学。观察到的病理变化可分为：骨质变化和软组织变化。骨质变化表现为吸收、纤维化、空骨陷窝和骨质分离。软组织变化有五种：继发性胆脂瘤形成、衬里上皮溃疡伴其下骨质吸收、外耳道及鼓膜上皮增厚、上皮下纤维化和耵聍腺萎缩。临床上，这些变化可表现为持续性外耳道炎，伴有耳漏和耳痛。
