Nakagawa Katsuhiro, Ihara Shingo, Yamaguchi Junko, Kuwana Tsukasa, Kinoshita Kosaku
Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Viruses. 2025 Jun 6;17(6):822. doi: 10.3390/v17060822.
The efficacy of steroid pulse therapy for treating severe coronavirus disease (COVID-19) pneumonia remains unclear. This study aimed to determine the efficacy of steroid pulse therapy for severe COVID-19 pneumonia in patients who did not respond to conventional therapy, including steroids. We included 76 patients with severe COVID-19 pneumonia treated with steroids in this single-facility retrospective observational study. Severe COVID-19 pneumonia was defined as requiring high-concentration oxygen administration (oxygen mask with reservoir mask (RM) > 6 L/min), high-flow nasal cannula oxygen therapy, or ventilatory support for respiratory control. The patient characteristics at admission and changes in them over time were examined in (a) a survival vs. death group, and (b) a steroid pulse vs. non-steroid pulse therapy group. Steroid pulse therapy significantly improved the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen just after the therapy and after one week of therapy, but had no effect on the sequential organ failure assessment scores over time. Multivariate logistic regression analyses showed that remdesivir use was associated with better survival outcomes, while steroid pulse therapy was associated with poor outcomes. In conclusion, steroid pulse therapy did not improve the prognosis of patients with severe COVID-19 pneumonia any more effectively than conventional steroid therapy.
类固醇脉冲疗法治疗重症冠状病毒病(COVID-19)肺炎的疗效仍不明确。本研究旨在确定类固醇脉冲疗法对常规治疗(包括类固醇)无反应的重症COVID-19肺炎患者的疗效。在这项单机构回顾性观察研究中,我们纳入了76例接受类固醇治疗的重症COVID-19肺炎患者。重症COVID-19肺炎定义为需要高浓度吸氧(带储氧面罩(RM)的氧气面罩>6 L/分钟)、高流量鼻导管吸氧治疗或呼吸控制的通气支持。在(a)生存组与死亡组,以及(b)类固醇脉冲治疗组与非类固醇脉冲治疗组中,研究了入院时的患者特征及其随时间的变化。类固醇脉冲疗法在治疗后及治疗一周后显著提高了动脉血氧分压与吸入氧分数的比值,但对随时间变化的序贯器官衰竭评估评分没有影响。多因素逻辑回归分析表明,使用瑞德西韦与更好的生存结果相关,而类固醇脉冲疗法与不良结果相关。总之,类固醇脉冲疗法在改善重症COVID-19肺炎患者预后方面并不比传统类固醇疗法更有效。
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