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重症监护病房中,类固醇脉冲疗法导致严重急性呼吸综合征冠状病毒2(SARS-CoV-2)患者继发感染且预后不良:一项回顾性队列研究。

Steroid Pulse Therapy Leads to Secondary Infections and Poor Outcomes in Patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Intensive Care Units: A Retrospective Cohort Study.

作者信息

Nakagawa Katsuhiro, Ihara Shingo, Yamaguchi Junko, Kuwana Tsukasa, Kinoshita Kosaku

机构信息

Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.

出版信息

Viruses. 2025 Jun 6;17(6):822. doi: 10.3390/v17060822.


DOI:10.3390/v17060822
PMID:40573413
Abstract

The efficacy of steroid pulse therapy for treating severe coronavirus disease (COVID-19) pneumonia remains unclear. This study aimed to determine the efficacy of steroid pulse therapy for severe COVID-19 pneumonia in patients who did not respond to conventional therapy, including steroids. We included 76 patients with severe COVID-19 pneumonia treated with steroids in this single-facility retrospective observational study. Severe COVID-19 pneumonia was defined as requiring high-concentration oxygen administration (oxygen mask with reservoir mask (RM) > 6 L/min), high-flow nasal cannula oxygen therapy, or ventilatory support for respiratory control. The patient characteristics at admission and changes in them over time were examined in (a) a survival vs. death group, and (b) a steroid pulse vs. non-steroid pulse therapy group. Steroid pulse therapy significantly improved the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen just after the therapy and after one week of therapy, but had no effect on the sequential organ failure assessment scores over time. Multivariate logistic regression analyses showed that remdesivir use was associated with better survival outcomes, while steroid pulse therapy was associated with poor outcomes. In conclusion, steroid pulse therapy did not improve the prognosis of patients with severe COVID-19 pneumonia any more effectively than conventional steroid therapy.

摘要

类固醇脉冲疗法治疗重症冠状病毒病(COVID-19)肺炎的疗效仍不明确。本研究旨在确定类固醇脉冲疗法对常规治疗(包括类固醇)无反应的重症COVID-19肺炎患者的疗效。在这项单机构回顾性观察研究中,我们纳入了76例接受类固醇治疗的重症COVID-19肺炎患者。重症COVID-19肺炎定义为需要高浓度吸氧(带储氧面罩(RM)的氧气面罩>6 L/分钟)、高流量鼻导管吸氧治疗或呼吸控制的通气支持。在(a)生存组与死亡组,以及(b)类固醇脉冲治疗组与非类固醇脉冲治疗组中,研究了入院时的患者特征及其随时间的变化。类固醇脉冲疗法在治疗后及治疗一周后显著提高了动脉血氧分压与吸入氧分数的比值,但对随时间变化的序贯器官衰竭评估评分没有影响。多因素逻辑回归分析表明,使用瑞德西韦与更好的生存结果相关,而类固醇脉冲疗法与不良结果相关。总之,类固醇脉冲疗法在改善重症COVID-19肺炎患者预后方面并不比传统类固醇疗法更有效。

相似文献

[1]
Steroid Pulse Therapy Leads to Secondary Infections and Poor Outcomes in Patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Intensive Care Units: A Retrospective Cohort Study.

Viruses. 2025-6-6

[2]
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Cochrane Database Syst Rev. 2023-1-25

[3]
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Cochrane Database Syst Rev. 2022-6-13

[4]
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Cochrane Database Syst Rev. 2022-5-20

[5]
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PLoS Med. 2020-12

[6]
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Cochrane Database Syst Rev. 2022-3-9

[7]
High-dose glucocorticoids pulse-therapy for beta-coronaviridae pneumonia: a systematic literature review and case-series of Coronavirus disease-2019.

Clin Exp Rheumatol. 2021

[8]
Drug effectiveness for COVID-19 inpatients inferred from Japanese medical claim data using propensity score matching.

F1000Res. 2024-1-22

[9]
Safety evaluation of remdesivir administration in patients with severe renal impairment and coronavirus disease: a systematic review and meta-analysis.

BMC Infect Dis. 2025-6-2

[10]
Effectiveness of remdesivir in patients with COVID-19 and severe renal insufficiency: a nationwide cohort study in Japan.

Infect Dis (Lond). 2025-2

本文引用的文献

[1]
Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19.

Respir Res. 2023-8-9

[2]
Steroid Pulse Therapy as a Treatment for Patients With COVID-19 Pneumonia at an Intensive Care Unit: A Single-Center Retrospective Observational Study.

Cureus. 2023-3-20

[3]
Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study.

Crit Care. 2023-2-8

[4]
Steroid exposure and outcome in COVID-19 pneumonia.

BJA Open. 2023-3

[5]
Kinetics of Immune Subsets in COVID-19 Patients Treated with Corticosteroids.

Viruses. 2022-12-24

[6]
Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence.

Cochrane Database Syst Rev. 2022-11-17

[7]
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.

Lancet. 2022-5-21

[8]
Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia: a double-blind, randomised, placebo-controlled trial.

Eur Respir J. 2022-10

[9]
Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial.

Front Med (Lausanne). 2021-11-30

[10]
Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.

Microorganisms. 2021-9-23

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