Eser Alenezi Enfal, Amir Amalina, Alenezi Hussain Ali, Ugurlu Timucin
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Başıbüyük 34854, İstanbul, Türkiye.
School of Mechanical Engineering, College of Engineering, University Technology MARA, Shah Alam 40450, Malaysia.
Pharmaceutics. 2025 May 29;17(6):717. doi: 10.3390/pharmaceutics17060717.
: Polymeric monoaxial nanofibers are gaining prominence due to their numerous applications, particularly in functional scenarios such as wound management. The study successfully developed and built a special-purpose vessel and device for fabricating polymeric nanofibers. Fabrication of composite scaffolds from piezoelectric poly(vinylidenefluoride-trifluoroethylene) copolymer (PVDF-TrFE) nanofibers encapsulated with myrrh extract was investigated. : The gyrospun nanofibers were characterized using SEM, EDX, FTIR, XRD, and TGA to assess the properties of the composite materials. The study also investigated the release profile of myrrh extract from the nanofibers, demonstrating its potential for sustained drug delivery. The composite's antimicrobial properties were evaluated using the disc diffusion method against various pathogenic microbes, showcasing their effectiveness. : It was found that an 18% (/) PVDF-TrFE concentration produces the best fiber mats compared to 20% and 25%, resulting in an average fiber diameter of 411 nm. Myrrh extract was added in varying amounts (10%, 15%, and 20%), with the best average fiber diameter identified at 10%, measuring 436 nm. The results indicated that the composite nanofibers were uniform, bead-free, and aligned without myrrh. The study observed a cumulative release of 79.66% myrrh over 72 h. The release profile showed an initial burst release of 46.85% within the first six hours, followed by a sustained release phase. Encapsulation efficiency was 89.8%, with a drug loading efficiency of 30%. Antibacterial activity peaked at 20% myrrh extract. was the most sensitive pathogen to myrrh extract. : Due to the piezoelectric effect of PVDF-TrFE and the significant antibacterial activity of myrrh, the prepared biohybrid nanofibers will open new avenues toward tissue engineering and wound healing applications.
聚合物单轴纳米纤维因其众多应用而日益受到关注，特别是在伤口处理等功能场景中。该研究成功开发并制造了一种用于制造聚合物纳米纤维的专用容器和设备。研究了用没药提取物包裹的压电聚（偏二氟乙烯 - 三氟乙烯）共聚物（PVDF-TrFE）纳米纤维制备复合支架。采用扫描电子显微镜（SEM）、能谱仪（EDX）、傅里叶变换红外光谱仪（FTIR）、X射线衍射仪（XRD）和热重分析仪（TGA）对旋转纺丝纳米纤维进行表征，以评估复合材料的性能。该研究还研究了没药提取物从纳米纤维中的释放曲线，证明了其在持续药物递送方面的潜力。使用纸片扩散法针对各种致病微生物评估了复合材料的抗菌性能，展示了其有效性。研究发现，与20%和25%相比，18%（/）的PVDF-TrFE浓度产生的纤维毡最佳，平均纤维直径为411纳米。没药提取物以不同量（10%、15%和20%）添加，最佳平均纤维直径在10%时确定，为436纳米。结果表明，复合纳米纤维均匀、无珠且在没有没药的情况下排列整齐。该研究观察到在72小时内没药的累积释放率为79.66%。释放曲线显示在前六小时内初始突发释放率为46.85%，随后是持续释放阶段。包封率为89.8%，载药率为30%。抗菌活性在20%没药提取物时达到峰值。是对没药提取物最敏感的病原体。由于PVDF-TrFE的压电效应和没药的显著抗菌活性，制备的生物杂交纳米纤维将为组织工程和伤口愈合应用开辟新途径。
