Bisht Supriya, Roger Kim, Al-Mulaabed Sharef, Kupferman Fernanda E
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, USA.
Department of Pediatrics, Division of Neonatology, One Brooklyn Health - Brookdale Hospital Medical Center, Brooklyn, USA.
Cureus. 2025 May 27;17(5):e84906. doi: 10.7759/cureus.84906. eCollection 2025 May.
To explore the association between absolute monocyte count (AMC) and necrotizing enterocolitis (NEC) in preterm neonates and to assess whether a fall in AMC can be used as a biomarker to predict an increased risk for NEC.
This was a retrospective study of preterm neonates with NEC or a first episode of feeding intolerance (FI). Their complete blood count (CBC) was evaluated for AMC at three time points, first at baseline, second at the onset of NEC/FI, and third afterwards. Statistical analysis was done using Student's t-test and the chi-squared test. The p-value of <0.05 was considered significant.
Of the total 92 newborns, 29 (31.5%) had NEC, while 63 (68.5%) had FI. NEC and FI groups were comparable in gestational age (GA) and birth weight. There was a significant increase in AMC in the FI group (p<0.001) from baseline to the onset of FI. However, the AMC had a fall in the NEC group from baseline to the onset of NEC, which was not statistically significant (p=0.074).
A decrease in AMC was associated with the presence of NEC. A fall in the AMC could be a biomarker to identify an increased risk of NEC in preterm neonates with feeding problems.
探讨早产儿绝对单核细胞计数（AMC）与坏死性小肠结肠炎（NEC）之间的关联，并评估AMC下降是否可作为预测NEC风险增加的生物标志物。
这是一项针对患有NEC或首次出现喂养不耐受（FI）的早产儿的回顾性研究。在三个时间点评估他们的全血细胞计数（CBC）中的AMC，第一个时间点是基线，第二个时间点是NEC/FI发作时，第三个时间点是之后。使用学生t检验和卡方检验进行统计分析。p值<0.05被认为具有统计学意义。
在总共92例新生儿中，29例（31.5%）患有NEC，而63例（68.5%）患有FI。NEC组和FI组在胎龄（GA）和出生体重方面具有可比性。FI组从基线到FI发作时AMC显著增加（p<0.001）。然而，NEC组从基线到NEC发作时AMC下降，这在统计学上不显著（p=0.074）。
AMC降低与NEC的存在有关。AMC下降可能是识别有喂养问题的早产儿NEC风险增加的生物标志物。
