Division of Neonatology, CHOC Children's, Orange, CA, USA.
CHOC Children's Research Institute, Orange, CA, USA.
J Perinatol. 2024 Dec;44(12):1768-1773. doi: 10.1038/s41372-024-02070-7. Epub 2024 Aug 1.
We investigated the trends of blood absolute monocyte count (AMC) over 72 h after suspecting necrotizing enterocolitis (NEC).
A single center, retrospective study, the AMC was plotted over 72 h after NEC evaluation. Receiver operating characteristic (ROC) curve analysis assessed change in AMC to identify absence of NEC and different NEC stages.
In 130 infants, the AMC decreased in patients with NEC stage 2 or 3. Stages 2 and 3 NEC experienced a drop in AMC compared to an increase in no NEC, possible NEC, or positive culture (p < 0.05). AMC increase 24% or less can differentiate NEC stage 2/3 from possible NEC with an area under the curve (AUC) of 0.78. While decrease of more than 32% can differentiate stage 2/3 vs. possible or no NEC with AUC of 0.71.
DISCUSSION/CONCLUSIONS: A decrease in AMC can be an adjunct biomarker to confirm the diagnosis of NEC.
我们研究了疑似坏死性小肠结肠炎（NEC）后 72 小时内血液绝对单核细胞计数（AMC）的趋势。
一项单中心回顾性研究，在 NEC 评估后 72 小时内绘制 AMC。接收者操作特征（ROC）曲线分析评估 AMC 的变化以识别 NEC 缺失和不同的 NEC 阶段。
在 130 名婴儿中，NEC 2 或 3 期的 AMC 降低。与无 NEC、可能 NEC 或阳性培养相比，NEC 2 期和 3 期 NEC 的 AMC 下降（p < 0.05）。AMC 增加 24%或更少可将 NEC 2/3 期与可能的 NEC 区分开来，曲线下面积（AUC）为 0.78。而减少 32%以上可将 2/3 期与可能或无 NEC 区分开来，AUC 为 0.71。
讨论/结论：AMC 的减少可以作为辅助生物标志物来确认 NEC 的诊断。
