Matl Christina M, Jang Wooyoung, Salley Jordan R, Fort Callie L, Demke Joshua C, Tran Phat, Wang James C
Texas Tech University Health Sciences Center School of Medicine Lubbock Texas USA.
Department of Otolaryngology-Head and Neck Surgery University of Texas Southwestern Medical School Dallas Texas USA.
Laryngoscope Investig Otolaryngol. 2025 Jun 25;10(3):e70189. doi: 10.1002/lio2.70189. eCollection 2025 Jun.
Basic science studies have shown that essential oils have antibacterial and anti-inflammatory effects in the nasal mucosa. However, clinical studies examining the effect of essential oils on patient outcomes are limited. The aim of this systematic review is to evaluate the patient outcomes following treatment of acute rhinosinusitis with essential oils.
PubMed, Ovid, Cochrane, and Embase computerized searches were performed to include results published up to December 2023. Two independent reviewers (C.M.M. and W.J.) conducted data extraction following a predetermined protocol, with any discrepancies reviewed by the senior author (J.C.W.).
Five RCTs investigated the treatment of rhinosinusitis with essential oils in capsule form. Essential oils included in the studies were Cineole, Myrtol (ELOM-080), Sinupret (BNO 1016), and Tavipec. Significant improvements in rhinological symptoms were seen in Cinole compared to placebo, Cinole compared to an herbal compound similar in composition to Sinupret, Tavipec compared to placebo, and ELOM-080 compared to placebo. Outcome measures included nasal obstruction, nasal drainage, facial pressure, headache, fatigue, and fever. Little difference in patient-reported rhinological symptom improvement was seen in ELOM-080 compared to BNO 1016 using a 5-point Likert Scale. Minimal adverse effects were observed in patients treated with essential oils with the most common adverse effect being mild gastrointestinal upset.
Patients using essential oils reported improvement in acute rhinosinusitis symptoms in all studies reviewed, despite differences in methodology and outcome measures. These improvements were statistically significant in all the studies.
Level 1 based on "The Oxford 2011 Levels of Evidence".
基础科学研究表明，精油对鼻黏膜具有抗菌和抗炎作用。然而，关于精油对患者预后影响的临床研究有限。本系统评价的目的是评估用精油治疗急性鼻窦炎后的患者预后。
进行PubMed、Ovid、Cochrane和Embase计算机检索，纳入截至2023年12月发表的结果。两名独立审阅者（C.M.M.和W.J.）按照预定方案进行数据提取，任何差异由资深作者（J.C.W.）审核。
五项随机对照试验研究了用胶囊形式的精油治疗鼻窦炎。研究中使用的精油包括桉叶油素、桃金娘油（ELOM - 080）、仙璐贝（BNO 1016）和塔维佩克。与安慰剂相比，桉叶油素、与成分与仙璐贝相似的草药化合物相比的桉叶油素、塔维佩克与安慰剂相比、ELOM - 080与安慰剂相比，鼻科症状均有显著改善。结局指标包括鼻塞、流涕、面部压迫感、头痛、疲劳和发热。使用5点李克特量表，ELOM - 080与BNO 1016相比，患者报告的鼻科症状改善差异不大。使用精油治疗的患者观察到的不良反应最小，最常见的不良反应是轻度胃肠道不适。
在所有纳入综述的研究中，使用精油的患者报告急性鼻窦炎症状有所改善，尽管研究方法和结局指标存在差异。这些改善在所有研究中均具有统计学意义。
根据“2011年牛津证据级别”为1级。
