A comprehensive systematic review and meta-analysis of uterine cancer in Asian countries.

BACKGROUND

Uterine cancer ranks among the leading causes of mortality in women, particularly prevalent in countries with low to moderate income levels. Present treatment and healthcare success rates are assessed by the survival rate index. This study aimed to determine the uterine cancer survival rate in Asia.

METHODS

Five international databases were analyzed to perform this systematic review: Medline/PubMed, ProQuest, Scopus, Web of Knowledge, and Google Scholar, until the end of August 2021. The Newcastle-Ottawa quality assessment form was utilized in the evaluation of quality for cohort studies. "I2 statistic and Cochran test were used to check the analysis process and assess the heterogeneity among the studies. Also, the study year was used as the basis for a meta-regression analysis.

RESULTS

The study covered 75 papers in total. The survival rates of uterine cancer after one, three, five, and seven years are 76.68% (95% CI, 66.76-78.61), 63.56% (95% CI, 58.60-68.37), 59.04% (95% CI, 55.62-62.43), and 57.86% (95% CI, 51.16-64.42) according to the random model. Furthermore, according to the outcomes of the meta-regression, there was no correlation found between the study year and the survival rate.

CONCLUSIONS

Compared to European and American countries, Asian countries have a poorer uterine cancer survival rate, which makes it crucial to improve the survival rate of patients through ensuring early diagnosis of the disease in its early stages and providing new diagnostic methods, modified surgical techniques, and targeted therapies.