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非法药物传感器:基于太赫兹光子晶体光纤的性能评估与识别

Illegal drugs sensor: Performance evaluation and identification based on terahertz photonic crystal fiber.

作者信息

Khandakar Kayab, Upoma Jabin Tasnin, Hasan Taib, Ferdous A H M Iftekharul, Kundu Diponkar, Faruk Md Omar, Ali Md Feroz, Shaun Md Shahorin Islam

机构信息

Department of Electrical and Electronic Engineering, Pabna University of Science and Technology, Pabna, Bangladesh.

出版信息

PLoS One. 2025 Jun 27;20(6):e0327013. doi: 10.1371/journal.pone.0327013. eCollection 2025.

Abstract

Excessive hormone release, the possibility of sleep disturbances, and a brief and quick improvement in the functioning of many organs, the physiological system, the nerves, etc. are all consequences of the abuse of incentive medications. Illegal narcotics have terrible long-term impacts on human health, including the possibility of death, in addition to their immediate effects. These consequences highlight the need for more obviousness and accuracy in the detection of illicit drugs, as well as for their detection to be done gently, effectively, and consistently. This work introduces an illicit drug sensor based on PCF, with an eye toward these as the primary targets. Three illegal drugs - ketamine, amphetamine, and cocaine - have been simulated for the sensor. Two types of circular air holes in cladding of varying sizes have been developed for a single core PCF. The cladding has three-layer chain and wind turbine-shaped air holes, and a circular air hole in the core region that will be used to field test drug samples, all included to achieve low confinement losses and high sensitivity. A maximum Relative Sensitivity (RS) of 99.92%, 99.12% and 98.83% at ketamine, amphetamine, and cocaine respectively is revealed by the recently established PCF analysis, which was presented out right away. Furthermore, we looked at the Confinement Loss (CL) associated with these illicit drugs, which was around 1.275 × 10-7 dB/m, 2.653 × 10-9 dB/m, and 4.106 × 10-10 dB/m, besides Effective Material Loss (EML) of 0.0042 cm-1, 0.0044 cm-1 and 0.0045 cm-1. Refractive index changes in PCF are usually the cause of action for PCF-based biosensors. These modifications have an impact on how light travels within the fiber. Drug molecules interact with light as a result of changes in the optical properties of the core that occur during light propagation through it.

摘要

滥用刺激性药物会导致激素过度释放、睡眠障碍,以及许多器官、生理系统、神经等功能的短暂快速改善。非法麻醉品除了会产生即时影响外,还会对人类健康造成可怕的长期影响,包括死亡的可能性。这些后果凸显了在非法药物检测中需要更加明显和准确,以及检测要温和、有效且一致。这项工作引入了一种基于光子晶体光纤(PCF)的非法药物传感器,将这些作为主要目标。该传感器对三种非法药物——氯胺酮、苯丙胺和可卡因进行了模拟。为单芯光子晶体光纤开发了两种不同尺寸的包层圆形气孔。包层有三层链状和风力涡轮机形状的气孔,以及芯区的一个圆形气孔,用于现场测试药物样本,所有这些都是为了实现低限制损耗和高灵敏度。最近进行的光子晶体光纤分析显示,在氯胺酮、苯丙胺和可卡因处的最大相对灵敏度(RS)分别为99.92%、99.12%和98.83%,该分析结果立即公布。此外,我们还研究了与这些非法药物相关的限制损耗(CL),其分别约为1.275×10 -7 dB/m、2.653×10 -9 dB/m和4.106×10 -10 dB/m,以及有效材料损耗(EML)分别为0.0042 cm -1、0.0044 cm -1和0.0045 cm -1。光子晶体光纤中的折射率变化通常是基于光子晶体光纤的生物传感器的作用原因。这些变化会影响光在光纤内的传播方式。在光通过芯区传播期间,由于芯区光学特性的变化,药物分子会与光相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe4/12204572/a3c21419896a/pone.0327013.g001.jpg

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