Alvarez-Aponte Zoila I, Procknow Rebecca R, Taga Michiko E
Department of Plant and Microbial Biology, University of California, Berkeley, California, USA; email:
Annu Rev Microbiol. 2025 Jun 27. doi: 10.1146/annurev-micro-051024-044734.
Microbial communities in different environments have major impacts on global nutrient cycling and on the health of host organisms. However, the complexity of microbial communities complicates the investigation of how interactions among numerous microbial species, each with distinct features and metabolic capabilities, affect global processes. In this review, we describe the corrinoid model for investigating microbial community interactions across scales, from individual microbes to complex natural communities. Corrinoids are the vitamin B12 (cobalamin) family of organometallic cofactors. While numerous metabolic processes across all domains of life require corrinoids, only a fraction of bacterial and archaeal species produce them. This structurally diverse set of shared nutrients influences community structure in different ways. Knowledge about corrinoid biology at each scale informs and reinforces a robust model that can be expanded to increase our understanding of microbial communities.
不同环境中的微生物群落对全球养分循环和宿主生物的健康有着重大影响。然而，微生物群落的复杂性使得研究众多具有不同特征和代谢能力的微生物物种之间的相互作用如何影响全球进程变得复杂。在这篇综述中，我们描述了类咕啉模型，用于研究从单个微生物到复杂自然群落等不同尺度上的微生物群落相互作用。类咕啉是维生素B12（钴胺素）家族的有机金属辅因子。虽然生命所有领域的众多代谢过程都需要类咕啉，但只有一小部分细菌和古菌物种能够产生它们。这组结构多样的共享养分以不同方式影响群落结构。关于每个尺度上类咕啉生物学的知识为一个强大的模型提供了信息并加强了该模型，这个模型可以扩展以增进我们对微生物群落的理解。
