Wiriyaamornchai Pannipa, Santeerapharp Alena
Department of Otorhinolaryngology-Head & Neck surgery, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Bangkok, Thailand.
Eur Arch Otorhinolaryngol. 2025 Jun 27. doi: 10.1007/s00405-025-09530-6.
This prospective double-blind randomized controlled trial aimed to assess the benefits of PRP therapy in enhancing wound healing, reducing post-operative bleeding, and alleviating pain in patients undergoing tonsillectomy. By comparing the outcomes of tonsillectomy wounds treated with PRP versus saline.
The study included 30 patients undergoing tonsillectomy, who were randomly assigned to receive PRP injections on one side and saline injections on the other side at the wound base. Pain levels, wound healing characteristics, and surgical complications such as bleeding were assessed for 28 days post-surgery.
In this study, there were no cases of post-operative bleeding in the surgical wounds on both sides of all patients. The pain level of the side injected with PRP is statistically significantly lower than the control side from the first day to the 5th day after surgery, there is no statistically significant difference in the pain level between both groups after the 6th day after surgery. The side injected with PRP had significantly faster re-epithelialization on days 7 and 14 post-surgery.
This study demonstrates the potential benefits of using PRP in promoting wound healing and reducing pain after tonsillectomy. The findings indicate that PRP injections can be a safe and effective treatment option for patients undergoing tonsillectomy.
这项前瞻性双盲随机对照试验旨在评估富血小板血浆（PRP）疗法在促进扁桃体切除术后患者伤口愈合、减少术后出血和减轻疼痛方面的益处。通过比较PRP治疗的扁桃体切除伤口与生理盐水治疗的伤口的结果。
该研究纳入了30例接受扁桃体切除术的患者，他们被随机分配在伤口底部一侧接受PRP注射，另一侧接受生理盐水注射。术后28天评估疼痛水平、伤口愈合特征以及出血等手术并发症。
在本研究中，所有患者两侧手术伤口均未发生术后出血。术后第1天至第5天，注射PRP一侧的疼痛水平在统计学上显著低于对照侧，术后第6天两组之间的疼痛水平无统计学显著差异。术后第7天和第14天，注射PRP一侧的再上皮化明显更快。
本研究证明了使用PRP促进扁桃体切除术后伤口愈合和减轻疼痛的潜在益处。研究结果表明，PRP注射对于接受扁桃体切除术的患者可能是一种安全有效的治疗选择。
