Gökçe Kütük Sinem, Özdaş Talih
Department of Otorhinolaryngology, Aydın State Hospital, Aydın, Turkey.
Department of Otorhinolaryngology, University of Health Sciences Adana City Hospital, Adana, Turkey.
Eur Arch Otorhinolaryngol. 2019 Feb;276(2):489-495. doi: 10.1007/s00405-018-5211-1. Epub 2018 Nov 20.
To compare the short-term outcomes of pediatric patients who underwent tonsillectomy alone vs. tonsillectomy plus platelet-rich plasma (PRP) therapy in terms of postoperative pain, appetite status, analgesia requirement, and bleeding complications.
This study included a total of 80 pediatric tonsillectomy patients (53.8% female, 46.2% male, aged 4-16 years), who were randomly allocated into tonsillectomy alone (TA group; n = 40) and tonsillectomy plus PRP therapy (TPRP group, n = 40) groups. Patient demographic data (age, gender) and postoperative data of visual analog scale (VAS) pain scores (postoperative 2nd hour, 1-10 days), appetite scores (postoperative 1-7 days), and analgesia requirement (postoperative 1-10 days) and bleeding complications were recorded.
A significant gradual decrease was noted in pain scores starting from the 3rd postoperative day reaching 0.0 ± 0.0 and 0.50 ± 0.88 on Day 10 in the TPRP and TA groups, respectively (p < 0.001 for each). Compared to the TA group, the TPRP group was associated with significantly lower pain scores (Day 1 to Day 10), better appetite scores (Day 1 to Day 6), a lower requirement for analgesia (Day1 to Day 10) and fewer common bleeding complications (1 vs. 4 patients) in the postoperative period (p < 0.001 for each).
In conclusion, this study of pediatric tonsillectomy patients revealed the superiority of tonsillectomy with PRP over tonsillectomy alone in terms of effectiveness in reducing post-tonsillectomy pain and improving appetite status, together with a lower requirement for analgesia and a reduced risk of post-tonsillectomy bleeding during the first 10 postoperative days.
比较单纯扁桃体切除术与扁桃体切除术加富血小板血浆（PRP）治疗的儿科患者在术后疼痛、食欲状况、镇痛需求和出血并发症方面的短期结局。
本研究共纳入80例儿科扁桃体切除术患者（女性占53.8%，男性占46.2%，年龄4 - 16岁），随机分为单纯扁桃体切除术组（TA组；n = 40）和扁桃体切除术加PRP治疗组（TPRP组，n = 40）。记录患者的人口统计学数据（年龄、性别）以及视觉模拟量表（VAS）疼痛评分（术后第2小时、术后1 - 10天）、食欲评分（术后1 - 7天）、镇痛需求（术后1 - 10天）和出血并发症等术后数据。
术后第3天起疼痛评分显著逐渐下降，TPRP组和TA组在第10天时分别降至0.0±0.0和0.50±0.88（每组p < 0.001）。与TA组相比，TPRP组在术后期间（第1天至第10天）疼痛评分显著更低、食欲评分更好（第1天至第6天）、镇痛需求更低（第1天至第10天）且常见出血并发症更少（1例对4例患者）（每组p < 0.001）。
总之，本项针对儿科扁桃体切除术患者的研究表明，扁桃体切除术联合PRP在减轻扁桃体切除术后疼痛、改善食欲状况方面优于单纯扁桃体切除术，同时在术后前10天镇痛需求更低且扁桃体切除术后出血风险降低。
