Rozga J, Jeppsson B, Bengmark S
J Surg Res. 1985 Nov;39(5):399-404. doi: 10.1016/0022-4804(85)90093-9.
The stimulatory effect of a growing kidney upon the liver was studied in rats with renoportal anastomosis (RPA) and contralateral nephrectomy. DNA synthesis, mitotic activity, and index of growth in the renoprival kidneys were independent of the shunt. Hepatic uptake of [Me-3H]thymidine was increased in both RPA-nephrectomized and sham-RPA-nephrectomized rats; however, in the latter group of animals the response was significantly greater. Results of the study suggest that stimulatory substance of renal origin is carried in the venous blood of a growing kidney. A nonspecific interaction between the renotropic and portal-borne hepatotrophic factors seemed to be responsible for stimulation of hepatic DNA synthesis. The study supports the view that mechanisms humoral in nature but not common promote reparative growth in different organs such as the liver and kidney.
在进行肾门吻合术（RPA）并对侧肾切除的大鼠中，研究了生长中的肾脏对肝脏的刺激作用。肾缺如肾脏的DNA合成、有丝分裂活性和生长指数与分流无关。在接受RPA肾切除和假手术-RPA肾切除的大鼠中，肝脏对[甲基-³H]胸腺嘧啶核苷的摄取均增加；然而，在后一组动物中，反应明显更大。研究结果表明，肾脏来源的刺激物质存在于生长中肾脏的静脉血中。促肾因子和门静脉携带的肝营养因子之间的非特异性相互作用似乎是刺激肝脏DNA合成的原因。该研究支持这样一种观点，即本质上是体液性但并非共同的机制促进肝脏和肾脏等不同器官的修复性生长。
