Lorenz W, Thon K, Ohmann C, Röher H D
Langenbecks Arch Chir. 1985;366:69-79. doi: 10.1007/BF01836608.
Asymptomatic recurrent ulcers following drugs and surgical therapy are true failures of treatment (Visick IV). Several types of bias at present do not allow any conclusion whether medical treatment and maintenance increase the rate of ulcer complications. The mechanisms of action for medical treatment with cimetidine and operative treatment with SPV are similar, but not identical. Bad compliance and incomplete vagotomies mainly account for success of mutual exchange between the two types of therapy. Using a decision tree with mortality as outcome recommendations are developed for a step-wise therapeutic concept in peptic ulcer patients.
药物和手术治疗后出现的无症状复发性溃疡是治疗的真正失败(Visick IV级)。目前存在的几种偏差使得无法得出关于药物治疗和维持治疗是否会增加溃疡并发症发生率的任何结论。西咪替丁药物治疗和选择性迷走神经切断术手术治疗的作用机制相似,但并不完全相同。依从性差和迷走神经切断不完全是两种治疗方法相互交换成功的主要原因。以死亡率为结果构建决策树,为消化性溃疡患者制定了逐步治疗方案的建议。