Chiba S
Life Sci. 1985 Oct 28;37(17):1597-604. doi: 10.1016/0024-3205(85)90478-3.
The effects of postnatal hypoxia at ten days of age on the pentylenetetrazol (PTZ)-induced seizure and amygdaloid kindling were investigated in male adult rats. The rats with postnatal hypoxia were significantly more susceptible to PTZ and had a significantly more easily induced amygdaloid kindling with a rapid propagation of afterdischarges to the contralateral amygdala than the control group. Light microscopic examination in one adult rat brain with postnatal hypoxia revealed no abnormal histopathological changes. The present study suggests that the consequences of postnatal hypoxia in rats remain for a long time as enhancement in seizure susceptibility.
研究了10日龄时出生后缺氧对成年雄性大鼠戊四氮（PTZ）诱发癫痫和杏仁核点燃的影响。与对照组相比，出生后缺氧的大鼠对PTZ明显更敏感，杏仁核点燃更容易诱导，后放电迅速传播至对侧杏仁核。对一只出生后缺氧的成年大鼠脑进行光镜检查，未发现异常组织病理学变化。本研究表明，大鼠出生后缺氧的后果会长期存在，表现为癫痫易感性增强。
