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有肝移植病史儿童的口腔健康状况

Oral Health Status of Children With a History of Liver Transplantation.

作者信息

Senirkentli Güler Burcu, Polat Simge, Onder N Sena

机构信息

Department of Pediatric Dentistry, Faculty of Dentistry, Baskent University, Ankara, Turkey.

出版信息

Pediatr Transplant. 2025 Aug;29(5):e70125. doi: 10.1111/petr.70125.

DOI:10.1111/petr.70125
PMID:40583134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12206942/
Abstract

OBJECTIVES

Chronic liver disease (CLD) in children imposes a significant health burden that impacts their development. This study aims to investigate how dental health outcomes change after liver transplantation in children, focusing particularly on the post-transplant period, examining the effect of immunosuppressive therapy, dental and skeletal anomalies in this patient group, caries experience, and dental age-related factors, and to develop targeted interventions for these problems.

METHODS

The prevalence of dental caries, the presence of odontogenic anomalies, the presence of jawbone anomalies, the need for periodontal treatment, the need for orthodontic treatment, and dental age were evaluated.

RESULTS

Fifty children (aged 6-12 years) with CLD and fifty healthy controls participated in the study. The analysis revealed no significant differences between the groups in terms of dental caries prevalence, presence of odontogenic anomalies, or jawbone anomalies. However, a statistically significant difference was found in dental age. While the analysis revealed no significant differences in dental caries prevalence between the groups, it is important to consider the possible moderating role of regular dental follow-ups after transplantation.

CONCLUSIONS

These findings offer valuable insights for dental professionals and pediatricians managing children with CLD. Future research with a larger sample size could further explore the association between CLD and dental age while investigating the potential influence of factors such as disease severity and medication use on oral health.

摘要

目的

儿童慢性肝病(CLD)带来了重大的健康负担,影响其发育。本研究旨在调查儿童肝移植后牙齿健康结果如何变化,特别关注移植后时期,研究免疫抑制治疗的影响、该患者群体中的牙齿和骨骼异常、龋齿经历以及与牙龄相关的因素,并针对这些问题制定有针对性的干预措施。

方法

评估龋齿患病率、牙源性异常的存在情况、颌骨异常的存在情况、牙周治疗需求、正畸治疗需求以及牙龄。

结果

50名患有CLD的儿童(年龄6至12岁)和50名健康对照参与了该研究。分析显示,两组在龋齿患病率、牙源性异常或颌骨异常方面无显著差异。然而,在牙龄方面发现了统计学上的显著差异。虽然分析显示两组之间的龋齿患病率无显著差异,但考虑移植后定期牙科随访可能起到的调节作用很重要。

结论

这些发现为管理患有CLD的儿童的牙科专业人员和儿科医生提供了有价值的见解。未来更大样本量的研究可以进一步探索CLD与牙龄之间的关联,同时研究疾病严重程度和药物使用等因素对口腔健康的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7b/12206942/0367db92596a/PETR-29-e70125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7b/12206942/cd2cbbd38729/PETR-29-e70125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7b/12206942/0367db92596a/PETR-29-e70125-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7b/12206942/cd2cbbd38729/PETR-29-e70125-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7b/12206942/0367db92596a/PETR-29-e70125-g001.jpg

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本文引用的文献

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Correlations between Dental Age, Skeletal Age, and Mandibular Morphologic Index Changes in Turkish Children in Eastern Anatolia and Their Chronological Age during the Pubertal Growth Spurt Period: A Cross-Sectional Study.安纳托利亚东部土耳其儿童青春期生长突增期牙龄、骨龄、下颌形态学指数变化与实际年龄的相关性:一项横断面研究
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Oral findings in children on liver transplantation programming: a scoping review.
肝移植编程中儿童的口腔发现:范围综述。
Rev Paul Pediatr. 2023 May 15;41:e2022095. doi: 10.1590/1984-0462/2023/41/2022095. eCollection 2023.
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Evaluation of Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry and Biochemical Markers.
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Bone demineralization in a cohort of Egyptian pediatric liver transplant recipients: Single center pilot study.埃及儿科肝移植受者队列中的骨矿物质减少:单中心初步研究。
Medicine (Baltimore). 2022 Nov 11;101(45):e31156. doi: 10.1097/MD.0000000000031156.
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Oral Dis. 2021 Sep;27(6):1346-1355. doi: 10.1111/odi.13439. Epub 2020 Jun 25.
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Oral Health Status of Kuwaiti Children with a History of Chronic Liver Disease.科威特慢性肝脏疾病患儿的口腔健康状况。
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Association between the time after transplantation and different immunosuppressive medications with dental and periodontal treatment need in patients after solid organ transplantation.实体器官移植患者移植后时间及不同免疫抑制药物与牙齿和牙周治疗需求之间的关联。
Transpl Infect Dis. 2018 Apr;20(2):e12832. doi: 10.1111/tid.12832. Epub 2018 Feb 21.
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