Senirkentli Güler Burcu, Polat Simge, Onder N Sena
Department of Pediatric Dentistry, Faculty of Dentistry, Baskent University, Ankara, Turkey.
Pediatr Transplant. 2025 Aug;29(5):e70125. doi: 10.1111/petr.70125.
Chronic liver disease (CLD) in children imposes a significant health burden that impacts their development. This study aims to investigate how dental health outcomes change after liver transplantation in children, focusing particularly on the post-transplant period, examining the effect of immunosuppressive therapy, dental and skeletal anomalies in this patient group, caries experience, and dental age-related factors, and to develop targeted interventions for these problems.
The prevalence of dental caries, the presence of odontogenic anomalies, the presence of jawbone anomalies, the need for periodontal treatment, the need for orthodontic treatment, and dental age were evaluated.
Fifty children (aged 6-12 years) with CLD and fifty healthy controls participated in the study. The analysis revealed no significant differences between the groups in terms of dental caries prevalence, presence of odontogenic anomalies, or jawbone anomalies. However, a statistically significant difference was found in dental age. While the analysis revealed no significant differences in dental caries prevalence between the groups, it is important to consider the possible moderating role of regular dental follow-ups after transplantation.
These findings offer valuable insights for dental professionals and pediatricians managing children with CLD. Future research with a larger sample size could further explore the association between CLD and dental age while investigating the potential influence of factors such as disease severity and medication use on oral health.
儿童慢性肝病(CLD)带来了重大的健康负担,影响其发育。本研究旨在调查儿童肝移植后牙齿健康结果如何变化,特别关注移植后时期,研究免疫抑制治疗的影响、该患者群体中的牙齿和骨骼异常、龋齿经历以及与牙龄相关的因素,并针对这些问题制定有针对性的干预措施。
评估龋齿患病率、牙源性异常的存在情况、颌骨异常的存在情况、牙周治疗需求、正畸治疗需求以及牙龄。
50名患有CLD的儿童(年龄6至12岁)和50名健康对照参与了该研究。分析显示,两组在龋齿患病率、牙源性异常或颌骨异常方面无显著差异。然而,在牙龄方面发现了统计学上的显著差异。虽然分析显示两组之间的龋齿患病率无显著差异,但考虑移植后定期牙科随访可能起到的调节作用很重要。
这些发现为管理患有CLD的儿童的牙科专业人员和儿科医生提供了有价值的见解。未来更大样本量的研究可以进一步探索CLD与牙龄之间的关联,同时研究疾病严重程度和药物使用等因素对口腔健康的潜在影响。