Alanazi Samyah
Clinical Laboratory Sciences Department College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia.
Anal Sci Adv. 2025 Jun 27;6(1):e70024. doi: 10.1002/ansa.70024. eCollection 2025 Jun.
Liquid chromatography-mass spectrometry (LC-MS) is a highly sophisticated analytical technique that has become indispensable for sample analysis across various scientific domains. In recent years, LC-MS has emerged as a cornerstone technology in comparative replicate sample analysis, particularly in the fields of proteomics, lipidomics and metabolomics. This review provides a comprehensive and in-depth exploration of LC-MS applications in biological, and applied sciences from the key aspects include (1) a historical perspective on LC-MS development and advancements; (2) its critical role in forensic investigations and environmental science; (3) its applications in food safety, quality control and pharmaceutical analysis and (4) its significance in the examination of pharmaceuticals and biological specimens. By presenting a broad and integrated understanding of LC-MS, this review underscores its transformative impact on life sciences and its expanding role in scientific research and innovation.
液相色谱 - 质谱联用（LC-MS）是一种高度精密的分析技术，已成为各个科学领域进行样品分析不可或缺的手段。近年来，LC-MS已成为比较重复样品分析中的一项基础技术，尤其在蛋白质组学、脂质组学和代谢组学领域。本综述从以下关键方面对LC-MS在生物学和应用科学中的应用进行了全面而深入的探讨：（1）LC-MS发展与进步的历史视角；（2）其在法医调查和环境科学中的关键作用；（3）其在食品安全、质量控制和药物分析中的应用；以及（4）其在药物和生物标本检测中的重要性。通过对LC-MS进行广泛而综合的解读，本综述强调了其对生命科学的变革性影响及其在科学研究与创新中不断扩大的作用。
