Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague, Czech Republic.
ALS Czech Republic, Na Harfe 223/9, 190 00 Prague, Czech Republic.
Molecules. 2023 Aug 5;28(15):5899. doi: 10.3390/molecules28155899.
(1) The occurrence and accumulation of pharmaceuticals and personal care products in the environment are recognized scientific concerns. Many of these compounds are disposed of in an unchanged or metabolized form through sewage systems and wastewater treatment plants (WWTP). WWTP processes do not completely eliminate all active substances or their metabolites. Therefore, they systematically leach into the water system and are increasingly contaminating ground, surface, and drinking water, representing a health risk largely ignored by legislative bodies. Especially during the COVID-19 pandemic, a significantly larger amount of medicines and protective products were consumed. It is therefore likely that contamination of water sources has increased, and in the case of groundwater with a delayed effect. As a result, it is necessary to develop an accurate, rapid, and easily available method applicable to routine screening analyses of potable water to monitor and estimate their potential health risk. (2) A multi-residue UHPLC-MS/MS analytical method designed for the identification of 52 pharmaceutical products was developed and used to monitor their presence in drinking water. (3) The optimized method achieved good validation parameters, with recovery of 70-120% of most analytes and repeatability achieving results within 20%. In real samples of drinking water, at least one analyte above the limit of determination was detected in each of the 15 tap water and groundwater samples analyzed. (4) These findings highlight the need for legislation to address pharmaceutical contamination in the environment.
(1) 药品和个人护理产品在环境中的出现和积累是公认的科学问题。这些化合物中的许多以未改变或代谢形式通过污水系统和废水处理厂（WWTP）处理。WWTP 工艺不能完全消除所有的活性物质或其代谢物。因此，它们会系统地浸出到水系中，并越来越多地污染地下水、地表水和饮用水，这代表了立法机构在很大程度上忽略的健康风险。特别是在 COVID-19 大流行期间，消耗了大量的药品和防护产品。因此，水源污染很可能增加，而对于地下水则具有延迟效应。因此，有必要开发一种准确、快速且易于获得的方法，适用于饮用水的常规筛选分析，以监测和评估其潜在的健康风险。(2) 设计了一种用于鉴定 52 种药物的多残留 UHPLC-MS/MS 分析方法，并用于监测其在饮用水中的存在。(3) 优化后的方法达到了良好的验证参数，大多数分析物的回收率为 70-120%，重复性在 20%以内。在分析的 15 个自来水和地下水样本的实际饮用水样本中，每个样本中都至少检测到一种超过限定值的分析物。(4) 这些发现强调了立法机构解决环境中药物污染问题的必要性。
