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Understanding and addressing anti-drug antibody formation in tumor necrosis factor-α inhibitor therapy for ankylosing spondylitis.

作者信息

Kim Tae-Jong

机构信息

Department of Rheumatology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

出版信息

J Rheum Dis. 2025 Jul 1;32(3):151-153. doi: 10.4078/jrd.2025.0067. Epub 2025 Jun 18.

DOI:10.4078/jrd.2025.0067
PMID:40584765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12202282/
Abstract
摘要

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4
Single-center series and systematic review of randomized controlled trials of malignancies in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis receiving anti-tumor necrosis factor alpha therapy: is there a need for more comprehensive screening procedures?类风湿关节炎、银屑病关节炎和强直性脊柱炎患者接受抗肿瘤坏死因子α治疗的恶性肿瘤单中心系列研究及随机对照试验的系统评价：是否需要更全面的筛查程序？
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本文引用的文献

1
Factors associated with anti-drug antibody production in ankylosing spondylitis patients treated with the infliximab biosimilar CT-P13.使用英夫利昔单抗生物类似药CT-P13治疗的强直性脊柱炎患者中与抗药抗体产生相关的因素。
J Rheum Dis. 2025 Apr 1;32(2):136-144. doi: 10.4078/jrd.2024.0114. Epub 2025 Jan 16.
2
Korean treatment recommendations for patients with axial spondyloarthritis.韩国关于中轴型脊柱关节炎患者的治疗建议。
J Rheum Dis. 2023 Jul 1;30(3):151-169. doi: 10.4078/jrd.2023.0025.
3
Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove.针对阿达木单抗的抗药物抗体的产生与 HLA-DR 肽结合槽内的变异有关。
JCI Insight. 2023 Feb 22;8(4):e156643. doi: 10.1172/jci.insight.156643.
4
Association between TNFi anti-drug antibodies, smoking, and disease activity in patients with inflammatory arthritis: Results from a Norwegian cross-sectional observational study.肿瘤坏死因子抑制剂（TNFi）抗药抗体、吸烟与炎性关节炎患者疾病活动度之间的关联：一项挪威横断面观察性研究的结果
Rheumatol Ther. 2022 Aug;9(4):1171-1179. doi: 10.1007/s40744-022-00464-7. Epub 2022 May 20.
5
Immunogenicity of TNF-Inhibitors.肿瘤坏死因子抑制剂的免疫原性。
Front Immunol. 2020 Feb 26;11:312. doi: 10.3389/fimmu.2020.00312. eCollection 2020.
6
Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial.甲氨蝶呤对阿达木单抗治疗中轴型脊柱关节炎的免疫原性和长期维持效果的影响：一项多中心随机试验。
RMD Open. 2020 Jan;6(1). doi: 10.1136/rmdopen-2019-001047. Epub 2020 Jan 9.
7
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.2019 年美国风湿病学会/脊柱关节炎协会/脊柱关节炎研究和治疗网络关于治疗强直性脊柱炎和非放射学中轴型脊柱关节炎的建议更新。
Arthritis Rheumatol. 2019 Oct;71(10):1599-1613. doi: 10.1002/art.41042. Epub 2019 Aug 22.
8
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis.类风湿关节炎中阿达木单抗和英夫利昔单抗抗药物抗体的发生率和危险因素：一项欧洲回顾性多队列分析。
Semin Arthritis Rheum. 2019 Jun;48(6):967-975. doi: 10.1016/j.semarthrit.2018.10.006. Epub 2018 Oct 12.
9
Efficacy and Safety Outcomes for Originator TNF Inhibitors and Biosimilars in Rheumatoid Arthritis and Psoriasis Trials: A Systematic Literature Review.在类风湿关节炎和银屑病试验中，原研 TNF 抑制剂和生物类似药的疗效和安全性结局：系统文献回顾。
BioDrugs. 2018 Jun;32(3):193-199. doi: 10.1007/s40259-018-0283-4.
10
Identification of HLA-DRB1 association to adalimumab immunogenicity.鉴定阿达木单抗免疫原性与 HLA-DRB1 关联性。
PLoS One. 2018 Apr 3;13(4):e0195325. doi: 10.1371/journal.pone.0195325. eCollection 2018.