早发性和晚发性阿尔茨海默病性痴呆的语言表现方面
Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.
作者信息
Gallée Jeanne, Gibbons Laura E, Choi Seo-Eun, Lee Michael, Scollard Phoebe, Trittschuh Emily H, Mez Jesse, Saykin Andrew J, Foldi Nancy S, Mukherjee Shubhabrata, Crane Paul K
机构信息
Center for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Alzheimer's Disease Research Center, University of Washington, Seattle WA 98195, USA.
出版信息
medRxiv. 2025 Jun 16:2025.06.13.25329521. doi: 10.1101/2025.06.13.25329521.
BACKGROUND
Early-onset Alzheimer's disease dementia (EOAD) is characterized by more pronounced cognitive decline than late-onset AD dementia (LOAD). Characteristic performance in spoken language remains undefined.
METHOD
A cross-sectional analysis of 1,189 people with EOAD and 4,646 with LOAD from the National Alzheimer's Coordinating Center (NACC).
RESULT
Based on data from their first NACC visit with AD, there was considerable heterogeneity in language performance across people with EOAD and LOAD. The distribution of naming ability was similar across these groups. On average, people with LOAD had better performance than people with EOAD for category fluency, letter fluency, and spoken lexical retrieval, and had lower Clinical Dementia Rating (CDR) language scores, though there was considerable overlap in all of the distributions for people with EOAD and people with LOAD.
DISCUSSION
At diagnosis, EOAD and LOAD language profiles are distinct. There is substantial variability in both groups in multiple aspects of language.
背景
早发性阿尔茨海默病性痴呆（EOAD）的特征是认知衰退比晚发性阿尔茨海默病性痴呆（LOAD）更明显。口语的特征性表现仍不明确。
方法
对来自国家阿尔茨海默病协调中心（NACC）的1189例EOAD患者和4646例LOAD患者进行横断面分析。
结果
根据他们首次到NACC进行阿尔茨海默病评估的数据，EOAD和LOAD患者的语言表现存在相当大的异质性。这些组之间的命名能力分布相似。平均而言，LOAD患者在类别流畅性、字母流畅性和口语词汇检索方面的表现优于EOAD患者，且临床痴呆评定量表（CDR）语言得分更低，不过EOAD患者和LOAD患者的所有分布中都存在相当大的重叠。
讨论
在诊断时，EOAD和LOAD的语言特征是不同的。两组在语言的多个方面都存在很大差异。
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