Zhao Gaiming, Zhang Ying, Wang Ke, Xu Long, Yin Mancai, Kong Xiangying, Zhu Chaozhi
Henan Key Lab of Meat Processing and Quality Safety Control Henan Agricultural University Zhengzhou China.
College of Food Science and Technology Henan Agricultural University Zhengzhou China.
Food Sci Nutr. 2025 Jun 27;13(7):e70522. doi: 10.1002/fsn3.70522. eCollection 2025 Jul.
The present study focused on the investigation of yak () meat peptides on immunity, antioxidant capacity, and hypoxia tolerance in hypotonic hypoxic mice using malondialdehyde (MDA), superoxide dismutase (SOD) kit, and so on. Yak protein powder was extracted first, and then peptides were obtained by INFOGEST static simulation of human gastrointestinal tract digestion. The results demonstrated that yak meat peptides increased the content of immune cells, oxygen transport capacity, and antioxidant enzyme activities in mice, while reducing oxidative stress damage in the body. In addition, protein expression of hypoxia-related genes hypoxia-inducible factor (HIF) and erythropoietin (EPO) was improved. This study can provide a theoretical foundation for reducing the harm of reactive oxygen species and free radicals to the human body and for the development and utilization of yak bioactive substances.
本研究聚焦于利用丙二醛（MDA）、超氧化物歧化酶（SOD）试剂盒等，研究牦牛肉肽对低渗性缺氧小鼠免疫力、抗氧化能力和耐缺氧能力的影响。首先提取牦牛肉蛋白粉，然后通过INFOGEST静态模拟人体胃肠道消化获得肽。结果表明，牦牛肉肽增加了小鼠免疫细胞含量、氧运输能力和抗氧化酶活性，同时减少了体内氧化应激损伤。此外，缺氧相关基因缺氧诱导因子（HIF）和促红细胞生成素（EPO）的蛋白表达得到改善。本研究可为减少活性氧和自由基对人体的危害以及牦牛生物活性物质的开发利用提供理论依据。
