Nan Jiaofen, Zhang Kaifan, Chen Beike, Xu Panpan, Fan Gaodeng, Zhang Siyuan, Ba Xiaojuan, Li Duan
School of Computer Science and Technology, Zhengzhou University of Light Industry, 136 Science Avenue, Zhengzhou, 450000, Henan Province, China.
Phys Eng Sci Med. 2025 Jun 30. doi: 10.1007/s13246-025-01555-9.
The prefrontal cortex (PFC) is known to play a crucial role in the complex process of human cognition such as emotion, memory, value and decision-making, and reward. However, the current functional subregion division is too coarse and the specific localization of clusters related to each task remains unclear. In the study, to clarify the specific role of different clusters in the PFC, a detailed subdivision of the prefrontal cortex was conducted based on evidence from human neuroimaging studies. Based on the predefined inclusion criteria, up to December 2022, a total of 186 studies related to emotion, memory, value decision-making, and reward were screened from the PubMed, Web of Science, and BrainMap functional databases. The Activation Likelihood Estimation (ALE) method was used to divide the prefrontal cortex regions by performing single-activation analysis, contrastive-activation analysis, and joint-activation analysis. The prefrontal brain area was divided into 15 functional sub-areas, each corresponding to unique activation or joint activation areas of emotion, memory, value and decision-making, and reward. The results showed that the prefrontal lobe of the brain plays different roles in the different subregions. The division of the prefrontal lobe has important clinical value for understanding and studying the relevant diseases.
前额叶皮质（PFC）在人类复杂的认知过程中发挥着关键作用，如情绪、记忆、价值判断、决策和奖赏等。然而，目前的功能亚区划分过于粗略，与每项任务相关的簇的具体定位仍不明确。在本研究中，为了阐明前额叶皮质中不同簇的具体作用，基于人类神经影像学研究的证据对前额叶皮质进行了详细细分。根据预先定义的纳入标准，截至2022年12月，从PubMed、科学网和BrainMap功能数据库中总共筛选出186项与情绪、记忆、价值决策和奖赏相关的研究。采用激活可能性估计（ALE）方法，通过进行单激活分析、对比激活分析和联合激活分析来划分前额叶皮质区域。前额叶脑区被划分为15个功能亚区，每个亚区对应于情绪、记忆、价值和决策以及奖赏的独特激活或联合激活区域。结果表明，大脑前额叶在不同亚区发挥着不同作用。前额叶的划分对于理解和研究相关疾病具有重要的临床价值。
