Quigley H A, Anderson D R
Am J Ophthalmol. 1977 May;83(5):709-17. doi: 10.1016/0002-9394(77)90138-6.
We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaining disk astrocytes into dense parallel layers across the nerve head. No astrocytic mitoses were observed and the estimated volume of astrocytes increased only slightly from normal. Among the astrocytes in atrophic disks, many capillaries had patent lumens and ultrastructurally normal endothelial cells. Pallor of the optic disk seems to result from a decrease in the transmission of light into the cytoarchitecture of the atrophic nerve head, not from the absence of capillaries or from extensive astrocytic proliferation.
我们研究了眶尖部视神经横断导致视神经变性的松鼠猴视神经乳头的临床和显微镜下表现。视盘苍白的眼底镜发展与神经纤维束的丧失以及剩余视盘星形胶质细胞重新排列成横跨神经乳头的致密平行层相一致。未观察到星形胶质细胞有丝分裂，星形胶质细胞的估计体积仅比正常略有增加。在萎缩视盘中的星形胶质细胞之间，许多毛细血管管腔通畅，内皮细胞超微结构正常。视盘苍白似乎是由于进入萎缩性神经乳头细胞结构的光传导减少所致，而非由于毛细血管缺失或星形胶质细胞广泛增殖。
